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侵袭性曲霉菌病伴多部位感染、纵隔炎和心脏侵袭

Invasive Aspergillosis With Multiple Locations, Mediastinitis, and Cardiac Invasion.

作者信息

Choudhary Anil Kumar, Singhal Manphool, Kaur Navjyot, Shrimanth Yamasandi Siddegowda, Shaw Manish, Kumar Suraj, Ahuja Nishtha, Kumar Aditya, Rohit Manoj Kumar

机构信息

Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Department of Radiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

JACC Case Rep. 2024 Dec 4;29(23):102770. doi: 10.1016/j.jaccas.2024.102770.

DOI:10.1016/j.jaccas.2024.102770
PMID:39691336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11646926/
Abstract

A 25-year-old man reporting weight loss and constitutional symptoms was empirically treated for tuberculosis. Following acute seizures, the patient underwent cerebral imaging and was diagnosed with multiple nonischemic cerebral lesions. Thoracic imaging revealed fibrosing mediastinitis infiltrating and obscuring the left atrium and left ventricle. Results of a skin nodule biopsy revealed fungal hyphae, and invasive aspergillosis was finally diagnosed.

摘要

一名25岁体重减轻并伴有全身症状的男性被经验性地诊断为肺结核并接受治疗。在急性癫痫发作后，该患者接受了脑部成像检查，被诊断为多发性非缺血性脑病变。胸部成像显示纤维性纵隔炎浸润并遮盖了左心房和左心室。皮肤结节活检结果显示有真菌菌丝，最终确诊为侵袭性曲霉病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/79a831f11cf7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/4503dcc042c3/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/197570f2046d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/e885fcdbb211/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/4d2150fd41d5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/da168aa31058/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/b331e494fc3e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/79a831f11cf7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/4503dcc042c3/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/197570f2046d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/e885fcdbb211/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/4d2150fd41d5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/da168aa31058/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/b331e494fc3e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c04/11646926/79a831f11cf7/gr6.jpg

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本文引用的文献

1
Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.曲霉病诊断和管理实践指南：美国感染病学会2016年更新版
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Fibrosing mediastinitis due to Aspergillus with dominant cardiac involvement: report of two autopsy cases with review of literature.曲霉菌致纤维性纵隔炎并以心脏为主导侵犯：两例尸检病例报告并文献复习
Cardiovasc Pathol. 2014 Nov-Dec;23(6):354-7. doi: 10.1016/j.carpath.2014.05.005. Epub 2014 Jun 5.
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Pol Arch Med Wewn. 2009 Nov;119(11):752-5.
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Sarcoidosis-associated fibrosing mediastinitis with resultant pulmonary hypertension: a case report and review of the literature.结节病相关性纤维性纵隔炎伴发肺动脉高压：病例报告及文献复习。
Respiration. 2010;79(4):341-5. doi: 10.1159/000243786. Epub 2009 Oct 1.
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An unusual case of Aspergillus fibrosing mediastinitis.一例罕见的曲霉性纤维性纵隔炎病例。
Ann Thorac Surg. 2009 Oct;88(4):1352-4. doi: 10.1016/j.athoracsur.2009.02.087.
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Indian J Pathol Microbiol. 2001 Apr;44(2):141-3.
9
Granulomatous mediastinitis due to Aspergillus flavus in a nonimmunosuppressed patient.非免疫抑制患者中由黄曲霉引起的肉芽肿性纵隔炎。
Am J Med. 1981 Apr;70(4):887-90. doi: 10.1016/0002-9343(81)90549-0.
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Sclerosing mediastinitis and terminal valvular endocarditis caused by fungus suggestive of Aspergillus species.
Am J Clin Pathol. 1971 Jul;56(1):91-6. doi: 10.1093/ajcp/56.1.91.