侵袭性曲霉菌病伴多部位感染、纵隔炎和心脏侵袭

Choudhary Anil Kumar, Singhal Manphool, Kaur Navjyot, Shrimanth Yamasandi Siddegowda, Shaw Manish, Kumar Suraj, Ahuja Nishtha, Kumar Aditya, Rohit Manoj Kumar

Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Department of Radiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

JACC Case Rep. 2024 Dec 4;29(23):102770. doi: 10.1016/j.jaccas.2024.102770.

A 25-year-old man reporting weight loss and constitutional symptoms was empirically treated for tuberculosis. Following acute seizures, the patient underwent cerebral imaging and was diagnosed with multiple nonischemic cerebral lesions. Thoracic imaging revealed fibrosing mediastinitis infiltrating and obscuring the left atrium and left ventricle. Results of a skin nodule biopsy revealed fungal hyphae, and invasive aspergillosis was finally diagnosed.

一名25岁体重减轻并伴有全身症状的男性被经验性地诊断为肺结核并接受治疗。在急性癫痫发作后，该患者接受了脑部成像检查，被诊断为多发性非缺血性脑病变。胸部成像显示纤维性纵隔炎浸润并遮盖了左心房和左心室。皮肤结节活检结果显示有真菌菌丝，最终确诊为侵袭性曲霉病。