Photocatalytic regioselective C-H bond functionalizations in arenes.

The direct functionalization of C-H bonds has revolutionized the field of synthetic organic chemistry by enabling efficient and atom-economical modification of arenes by avoiding prefunctionalization. However, the inherent challenges of inertness and regioselectivity in different C-H bonds, particularly for distal positions, necessitate innovative approaches. In this aspect, photoredox catalysis by utilizing both transition metal and organic photocatalysts has emerged as a powerful tool for addressing these challenges under mild reaction conditions. This review provides a comprehensive overview of recent progress in regioselective C-H functionalization in arenes photocatalysis. Emphasizing the strategies for achieving , , and -selectivity, we explore the mechanistic insights, catalyst designs, and the novel methodologies that have expanded the scope of C-H bond functionalization. This discussion aims to offer valuable perspectives for advancing the field and developing more efficient and sustainable synthetic methodologies.