Hu Jun, Pradhan Suman, Waiba Satyadeep, Das Shoubhik
Department of Chemistry, University of Bayreuth Universitätsstraße 30 95447 Bayreuth Germany
Chem Sci. 2024 Dec 9;16(3):1041-1070. doi: 10.1039/d4sc07491b. eCollection 2025 Jan 15.
The direct functionalization of C-H bonds has revolutionized the field of synthetic organic chemistry by enabling efficient and atom-economical modification of arenes by avoiding prefunctionalization. However, the inherent challenges of inertness and regioselectivity in different C-H bonds, particularly for distal positions, necessitate innovative approaches. In this aspect, photoredox catalysis by utilizing both transition metal and organic photocatalysts has emerged as a powerful tool for addressing these challenges under mild reaction conditions. This review provides a comprehensive overview of recent progress in regioselective C-H functionalization in arenes photocatalysis. Emphasizing the strategies for achieving , , and -selectivity, we explore the mechanistic insights, catalyst designs, and the novel methodologies that have expanded the scope of C-H bond functionalization. This discussion aims to offer valuable perspectives for advancing the field and developing more efficient and sustainable synthetic methodologies.
碳氢键的直接官能团化通过避免预官能团化实现芳烃的高效和原子经济修饰，从而彻底改变了合成有机化学领域。然而，不同碳氢键，特别是远端位置的碳氢键存在的惰性和区域选择性等固有挑战，需要创新方法。在这方面，利用过渡金属和有机光催化剂的光氧化还原催化已成为在温和反应条件下应对这些挑战的有力工具。本综述全面概述了芳烃光催化区域选择性碳氢键官能团化的最新进展。我们强调实现邻位、间位和对位选择性的策略，探讨其机理见解、催化剂设计以及拓展碳氢键官能团化范围的新方法。本讨论旨在为推动该领域发展以及开发更高效和可持续的合成方法提供有价值的观点。
