Park Grace S, Atluri Himachandana, DiNardo Courtney D, Guillroy Bryan, Horak Jean, Apostolidou Effrosyni, Buni Maryam, Bravo Guillermo Montalban, Pemmaraju Naveen
Department of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Leuk Res Rep. 2024 Nov 28;23:100485. doi: 10.1016/j.lrr.2024.100485. eCollection 2025.
Delayed hemolytic transfusion reaction (DHTR) poses a significant challenge in patients receiving blood transfusions. This case report highlights the complexities of managing DHTR in a newly diagnosed chronic myelomonocytic leukemia (CMML) patient with clinically significant JKa and little c antibodies during induction chemotherapy. A 46-year-old woman with CMML-2 who presented for induction chemotherapy was found to have hemolytic anemia. Due to presence of JKa and little c antibodies, she required intensive monitoring and supportive care measures. The coexistence of JKa and little c antibodies complicates transfusion management and chemotherapy tolerance in CMML patients.
迟发性溶血性输血反应（DHTR）给接受输血的患者带来了重大挑战。本病例报告强调了在一名新诊断的慢性粒单核细胞白血病（CMML）患者中管理DHTR的复杂性，该患者在诱导化疗期间具有临床意义的JKa抗体且几乎没有c抗体。一名因CMML-2前来接受诱导化疗的46岁女性被发现患有溶血性贫血。由于存在JKa抗体且几乎没有c抗体，她需要密切监测和支持性护理措施。JKa抗体和几乎没有c抗体的共存使CMML患者的输血管理和化疗耐受性变得复杂。
