吡咯烷类作为治疗病毒感染，特别是冠状病毒感染的主要蛋白酶抑制剂。
Pyrrolidines as Main Protease Inhibitors for Treating Viral Infections, in Particular, Coronavirus Infections.
作者信息
Sabnis Ram W
机构信息
Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States.
出版信息
ACS Med Chem Lett. 2024 Nov 15;15(12):2097-2098. doi: 10.1021/acsmedchemlett.4c00553. eCollection 2024 Dec 12.
Abstract
Provided herein are novel pyrrolidines as main protease inhibitors, pharmaceutical compositions, use of such compounds in treating viral infections, in particular, coronavirus infections, and processes for preparing such compounds.
摘要
本文提供了作为主要蛋白酶抑制剂的新型吡咯烷、药物组合物、此类化合物在治疗病毒感染特别是冠状病毒感染中的用途以及制备此类化合物的方法。
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本文引用的文献
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Design of inhibitors of SARS-CoV-2 papain-like protease deriving from GRL0617: Structure-activity relationships.基于 GRL0617 的 SARS-CoV-2 木瓜蛋白酶样蛋白酶抑制剂设计：结构-活性关系。
Bioorg Med Chem. 2024 Nov 1;113:117909. doi: 10.1016/j.bmc.2024.117909. Epub 2024 Sep 11.
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ACS Med Chem Lett. 2024 Jul 23;15(8):1186-1187. doi: 10.1021/acsmedchemlett.4c00331. eCollection 2024 Aug 8.
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