Kargbo Robert B
Usona Institute, Fitchburg, Wisconsin 53711-5300, United States.
ACS Med Chem Lett. 2024 Nov 11;15(12):2074-2076. doi: 10.1021/acsmedchemlett.4c00518. eCollection 2024 Dec 12.
The rapid advances in cancer research have led to novel therapeutic approaches focusing on previously undruggable targets and immune evasion mechanisms. Recent innovations exemplify these cutting-edge strategies, particularly in KRAS-targeting therapies using PROTAC technology and immune modulation to address resistance in cancer cells. These developments present promising methods for degrading oncogenic proteins and enhancing immune system responses, potentially transforming the cancer treatment landscape. This Patent Highlight showcases these breakthroughs, emphasizing their significant potential to transform cancer therapy.
癌症研究的快速进展催生了针对先前难以成药的靶点和免疫逃逸机制的新型治疗方法。最近的创新体现了这些前沿策略,特别是在使用PROTAC技术的KRAS靶向治疗和免疫调节以解决癌细胞耐药性方面。这些进展为降解致癌蛋白和增强免疫系统反应提供了有前景的方法,有可能改变癌症治疗格局。本专利亮点展示了这些突破,强调了它们在改变癌症治疗方面的巨大潜力。