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靶向癌症:通过免疫适应性调节和KRAS降解实现癌症治疗的新时代。

Targeting Cancer: A New Era in Cancer Therapy through Immune Fitness Modulation and KRAS Degradation.

作者信息

Kargbo Robert B

机构信息

Usona Institute, Fitchburg, Wisconsin 53711-5300, United States.

出版信息

ACS Med Chem Lett. 2024 Nov 11;15(12):2074-2076. doi: 10.1021/acsmedchemlett.4c00518. eCollection 2024 Dec 12.

Abstract

The rapid advances in cancer research have led to novel therapeutic approaches focusing on previously undruggable targets and immune evasion mechanisms. Recent innovations exemplify these cutting-edge strategies, particularly in KRAS-targeting therapies using PROTAC technology and immune modulation to address resistance in cancer cells. These developments present promising methods for degrading oncogenic proteins and enhancing immune system responses, potentially transforming the cancer treatment landscape. This Patent Highlight showcases these breakthroughs, emphasizing their significant potential to transform cancer therapy.

摘要

癌症研究的快速进展催生了针对先前难以成药的靶点和免疫逃逸机制的新型治疗方法。最近的创新体现了这些前沿策略,特别是在使用PROTAC技术的KRAS靶向治疗和免疫调节以解决癌细胞耐药性方面。这些进展为降解致癌蛋白和增强免疫系统反应提供了有前景的方法,有可能改变癌症治疗格局。本专利亮点展示了这些突破,强调了它们在改变癌症治疗方面的巨大潜力。

相似文献

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本文引用的文献

1
Overcoming the challenges of primary resistance and relapse after CAR-T cell therapy.克服 CAR-T 细胞治疗后原发性耐药和复发的挑战。
Expert Rev Clin Immunol. 2024 Jul;20(7):745-763. doi: 10.1080/1744666X.2024.2349738. Epub 2024 May 14.
2
Immunometabolism of CD8 T cell differentiation in cancer.癌症中 CD8 T 细胞分化的免疫代谢。
Trends Cancer. 2024 Jul;10(7):610-626. doi: 10.1016/j.trecan.2024.03.010. Epub 2024 Apr 30.
4
Targeting KRAS in cancer.针对癌症中的 KRAS 靶点。
Nat Med. 2024 Apr;30(4):969-983. doi: 10.1038/s41591-024-02903-0. Epub 2024 Apr 18.
5
Annual review of PROTAC degraders as anticancer agents in 2022.2022 年 PROTAC 降解剂作为抗癌药物的年度回顾。
Eur J Med Chem. 2024 Mar 5;267:116166. doi: 10.1016/j.ejmech.2024.116166. Epub 2024 Jan 25.
6
Unveiling the role of KRAS in tumor immune microenvironment.揭示 KRAS 在肿瘤免疫微环境中的作用。
Biomed Pharmacother. 2024 Feb;171:116058. doi: 10.1016/j.biopha.2023.116058. Epub 2024 Jan 2.

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