Shivappa Pooja, Parmar Satyam, Menezes Godfred A, Sekar Priyadharshini, Ahmad Hafiz, Hossain Ashfaque
Department of Biochemistry, Translational Medicinal Research Center, RAK Medical and Health Sciences University, Ras AL Khaimah, UAE.
Department of Pathology/Laboratory Head, RAK Hospital, Ras AL Khaimah, UAE.
J Pharm Bioallied Sci. 2024 Jul-Sep;16(3):93-103. doi: 10.4103/jpbs.jpbs_514_24. Epub 2024 Oct 17.
Coronavirus disease 2019 (COVID-19) was first reported in December 2019 in Wuhan, People's Republic of China, and caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), As the virus took hold in the world, health experts paced efforts to solve the unknown nature of this threat.
We studied the clinical characteristics, laboratory biomarkers of healthcare workers in the single center, analytical cross-sectional study conducted in tertiary care hospital of the UAE. Sample size of 600 HCWs were screened for SARS-CoV-2 by real-time reverse transcription polymerase chain reaction (rRT-PCR) assay using Seegene Allplex and Andis FAST SARS-CoV-2 RT-qPCR detection kits for a period of 6 months.
All the health care workers (HCWs) were vaccinated for the SARS-CoV-2. Out of these, 240 HCWs were reported to be positive. rRT-PCR with a Ct value of <38 was taken as positive >38. The laboratory investigations of the positive cases were collected and analysed further. A comparison of the laboratory tests was made between (I) COVID severe (Ct < 25) and nonsevere (Ct > 25) groups and (II) frontline workers and non-frontline workers. Besides finding short-term and sudden relief, investigators directed their efforts to provide a long-term solution for an ensuing pandemic that influenced all areas of life in unprecedented ways.
Awareness among healthcare workers and further long-term studies focusing on their mental health the overall wellness and especially the psychological burden on doctors have received heightened awareness in media and research publications. This information can assist in developing surveillance and infection and control policies and preparedness for future COVID epidemics in similar scenarios in the future.
2019年冠状病毒病(COVID-19)于2019年12月首次在中国武汉报告,由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起。随着该病毒在全球蔓延,健康专家加紧努力以了解这一威胁的未知特性。
我们在阿联酋一家三级护理医院进行了单中心分析性横断面研究,对医护人员的临床特征和实验室生物标志物进行了研究。在6个月的时间里,使用Seegene Allplex和Andis FAST SARS-CoV-2 RT-qPCR检测试剂盒,通过实时逆转录聚合酶链反应(rRT-PCR)检测法对600名医护人员进行了SARS-CoV-2筛查。
所有医护人员均接种了SARS-CoV-2疫苗。其中,240名医护人员被报告为阳性。rRT-PCR检测中,Ct值<38被判定为阳性,>38则为阴性。对阳性病例的实验室检查结果进行了进一步收集和分析。对(I)COVID重症组(Ct<25)和非重症组(Ct>25)以及(II)一线工作人员和非一线工作人员的实验室检查结果进行了比较。除了寻求短期和突发缓解措施外,研究人员还致力于为这场以前所未有的方式影响生活各个领域的疫情提供长期解决方案。
医护人员的意识以及针对他们心理健康、整体健康状况,尤其是医生心理负担的进一步长期研究,在媒体和研究出版物中受到了更高的关注。这些信息有助于制定监测、感染控制政策以及为未来类似情况下的COVID疫情做好准备。