Xu Xinling, Silveira Angela, Lundman Pia, Rahbar Afsar, Söderberg-Nauclér Cecilia
Department of Medicine Solna, Unit Microbial Pathogenesis, Karolinska Institutet, Stockholm, Sweden.
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
Int J Cardiol Heart Vasc. 2024 Dec 2;56:101570. doi: 10.1016/j.ijcha.2024.101570. eCollection 2025 Feb.
Efforts to understand atherosclerosis, a major cause of ischemic heart disease, have linked several lifestyle factors to increased risk for developing cardiovascular disease. Some studies suggest that cytomegalovirus (CMV), a widely prevalent herpesvirus, is reactivated in atherosclerotic plaques and associated with higher cardiovascular mortality risk. We aimed to explore whether CMV seropositivity and CMV-IgG antibody levels correlate with relevant biomarkers in a cohort of patients with myocardial infarction (MI) and matched controls.
We analyzed a dataset from 324 survivors of MI treated in Stockholm between 1996 and 2001. Blood samples collected three months after MI were used to measure protective Apo B100 autoantibodies, metabolic, and inflammatory biomarkers. CMV serology was performed on stored serum samples. Correlation analyses were conducted between biomarkers and CMV serostatus in 324 patients and age- and sex-matched controls. While CMV seroprevalence was equal, the CMV-IgG levels were higher in controls. Among various factors examined, CMV seropositive MI patients had elevated levels of plasminogen activator inhibitor-1 (PAI-1) and interleukin-6, along with lower levels of MMP-3, than CMV seronegative MI patients. CMV-IgG levels correlated positively with PAI-1 levels in patients. Although CMV seropositivity was associated with increased proinsulin levels, there was no correlation with diabetes diagnosis.
Our findings suggest an enhanced inflammatory and prothrombotic state in CMV seropositive patients after MI. Notably, patients had lower levels of CMV IgG than controls.
缺血性心脏病的主要病因是动脉粥样硬化，为了解该疾病所做的研究已将多种生活方式因素与心血管疾病发生风险增加联系起来。一些研究表明，巨细胞病毒（CMV）是一种广泛流行的疱疹病毒，在动脉粥样硬化斑块中被重新激活，并与较高的心血管死亡风险相关。我们旨在探讨在一组心肌梗死（MI）患者及其匹配的对照组中，CMV血清阳性和CMV-IgG抗体水平是否与相关生物标志物相关。
我们分析了1996年至2001年在斯德哥尔摩接受治疗的324例MI幸存者的数据集。MI后三个月采集的血样用于检测保护性载脂蛋白B100自身抗体、代谢和炎症生物标志物。对储存的血清样本进行CMV血清学检测。在324例患者及其年龄和性别匹配的对照组中，对生物标志物与CMV血清状态进行相关性分析。虽然CMV血清阳性率相同，但对照组的CMV-IgG水平更高。在检查的各种因素中，与CMV血清阴性的MI患者相比，CMV血清阳性的MI患者纤溶酶原激活物抑制剂-1（PAI-1）和白细胞介素-6水平升高，而基质金属蛋白酶-3水平较低。患者中CMV-IgG水平与PAI-1水平呈正相关。虽然CMV血清阳性与胰岛素原水平升高有关，但与糖尿病诊断无关。
我们的研究结果表明，MI后CMV血清阳性患者的炎症和血栓前状态增强。值得注意的是，患者的CMV IgG水平低于对照组。
