Inflammatory markers in acute myocardial infarction and the correlation with the severity of coronary heart disease.

INTRODUCTION

The inflammatory hypothesis of atherosclerosis is appealing in acute coronary syndromes, but the dynamics and precise role are not established.

OBJECTIVES

The study investigates the levels of C reactive protein (CRP), interleukin 1β (IL-1β) and stromal-derived factor 1α (SDF-1α) at the time of acute myocardial infarction (AMI) and at 1 and 6 months afterwards, compared with a control group.

RESULTS

In the acute phase of AMI, CRP and SDF-1α were significantly higher, while IL-1β showed lower levels compared with controls. CRP positively correlated with coronary stenosis severity (rho = 0.3, =.05) and negatively related with left ventricle ejection fraction (LVEF) at 1 month (rho= -0.43, =.05). IL-1β weakly correlated with the severity of coronary lesions (rho =0.29, =.02) and strongly with LVEF (rho= -0.8, =.05). SDF-1α, slightly correlated with LVEF at 1 month (rho = 0.22, =.01) and with the severity of coronary atherosclerosis (rho= -0.41, =.003).

CONCLUSIONS

CRP, IL-1β and SDF-1α have important dynamic in the first 6 months after AMI and CRP and SDF-1α levels correlated with the severity of coronary lesions and LVEF at 1 month after the acute ischaemic event.