Department of Cardiology, Clinical Emergency Hospital of Bucharest, Romania.
Cardio-thoracic Department, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
Ann Med. 2021 Dec;53(1):1041-1047. doi: 10.1080/07853890.2021.1916070.
The inflammatory hypothesis of atherosclerosis is appealing in acute coronary syndromes, but the dynamics and precise role are not established.
The study investigates the levels of C reactive protein (CRP), interleukin 1β (IL-1β) and stromal-derived factor 1α (SDF-1α) at the time of acute myocardial infarction (AMI) and at 1 and 6 months afterwards, compared with a control group.
In the acute phase of AMI, CRP and SDF-1α were significantly higher, while IL-1β showed lower levels compared with controls. CRP positively correlated with coronary stenosis severity (rho = 0.3, =.05) and negatively related with left ventricle ejection fraction (LVEF) at 1 month (rho= -0.43, =.05). IL-1β weakly correlated with the severity of coronary lesions (rho =0.29, =.02) and strongly with LVEF (rho= -0.8, =.05). SDF-1α, slightly correlated with LVEF at 1 month (rho = 0.22, =.01) and with the severity of coronary atherosclerosis (rho= -0.41, =.003).
CRP, IL-1β and SDF-1α have important dynamic in the first 6 months after AMI and CRP and SDF-1α levels correlated with the severity of coronary lesions and LVEF at 1 month after the acute ischaemic event.
动脉粥样硬化的炎症假说在急性冠状动脉综合征中很有吸引力，但动力学和确切作用尚未确定。
本研究旨在调查在急性心肌梗死（AMI）发生时以及随后 1 个月和 6 个月与对照组相比，C 反应蛋白（CRP）、白细胞介素 1β（IL-1β）和基质衍生因子 1α（SDF-1α）的水平。
在 AMI 的急性期，CRP 和 SDF-1α 显著升高，而 IL-1β 水平较低。CRP 与冠状动脉狭窄严重程度呈正相关（rho = 0.3，p =.05），与 1 个月时的左心室射血分数（LVEF）呈负相关（rho= -0.43，p =.05）。IL-1β 与冠状动脉病变严重程度呈弱相关（rho = 0.29，p =.02），与 LVEF 呈强相关（rho= -0.8，p =.05）。SDF-1α 与 1 个月时的 LVEF 轻度相关（rho = 0.22，p =.01），与冠状动脉粥样硬化严重程度呈强相关（rho= -0.41，p =.003）。
CRP、IL-1β 和 SDF-1α 在 AMI 后 6 个月内具有重要的动态变化，CRP 和 SDF-1α 水平与 1 个月时冠状动脉病变严重程度和 LVEF 相关。
