Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
The Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
J Infect Dis. 2022 Apr 1;225(7):1179-1188. doi: 10.1093/infdis/jiab364.
Previous studies have yielded conflicting results on the association between human cytomegalovirus (HCMV) and cardiovascular disease (CVD). This study examined associations between HCMV and incident CVD, ischaemic heart disease (IHD) and stroke.
This study included 8531 women and men of predominantly white ethnic background, aged 40-69 without prevalent CVD from the population-based UK Biobank study, recruited between 2006-2010 with HCMV antibody levels measured. CVD was ascertained via linkage to health administrative records collected until 2020. Multivariate Cox proportional-hazards models were used to determine associations between HCMV seropositivity and incident CVD, IHD and stroke. HCMV seropositive antibody levels in tertiles were used to assess dose-response associations.
Over a mean follow-up period of 10.2 years, HCMV seropositivity was not significantly associated with CVD (Cases = 626, Hazard Ratio [HR] =1.01, 95% confidence interval [CI], .86-1.20), IHD (Cases = 539, HR=1.03, 95% CI, .87-1.24) or stroke (Cases = 144, HR = 0.96, 95% CI, .68-1.36). There was no evidence of dose-response associations with any outcome.
We found no significant association between HCMV seropositivity and risk of CVD, IHD or stroke. Further research within understudied populations, such as those of non-white ethnicity, and CVD subtypes is warranted.
先前的研究对人类巨细胞病毒（HCMV）与心血管疾病（CVD）之间的关联得出了相互矛盾的结果。本研究检查了 HCMV 与心血管疾病、缺血性心脏病（IHD）和中风的发病风险之间的关联。
这项研究纳入了 8531 名主要为白种人背景的 40-69 岁的人群，他们来自于英国生物银行的人群队列研究，该研究于 2006 年至 2010 年期间招募，同时测量了他们的 HCMV 抗体水平。心血管疾病通过与截至 2020 年收集的健康管理记录进行关联来确定。使用多变量 Cox 比例风险模型来确定 HCMV 血清阳性与心血管疾病、IHD 和中风的发病风险之间的关联。使用三分位数的 HCMV 血清阳性抗体水平来评估剂量-反应关联。
在平均 10.2 年的随访期间，HCMV 血清阳性与心血管疾病（病例数=626，风险比[HR]=1.01，95%置信区间[CI]，.86-1.20）、IHD（病例数=539，HR=1.03，95% CI，.87-1.24）或中风（病例数=144，HR=0.96，95% CI，.68-1.36）均无显著相关性。对于任何结局，均未发现剂量-反应关系的证据。
我们发现 HCMV 血清阳性与心血管疾病、IHD 或中风的发病风险之间没有显著关联。需要在研究较少的人群中，如非白种人群和心血管疾病亚型中进行进一步研究。
