Sweeney V P, Perry T L, Price J D, Reeve C E, Godolphin W J, Kish S J
Neurology. 1985 Feb;35(2):180-4. doi: 10.1212/wnl.35.2.180.
We measured levels of gamma-aminobutyric acid (GABA) in the CSF and in the autopsied brain of patients with dialysis encephalopathy. GABA concentrations were low in the CSF of three of five living patients. Mean GABA content was reduced by 30 to 50% in five brain regions (frontal, occipital, and cerebellar cortex, caudate nucleus, and medial dorsal thalamus) in five fatal cases. GABA content was normal in brain regions where GABA is characteristically reduced in Huntington's disease. Choline acetyltransferase activity was diminished (by 25 to 35%) in cerebral cortex of the dialysis encephalopathy patients.
我们检测了透析性脑病患者脑脊液及尸检大脑中的γ-氨基丁酸（GABA）水平。五名存活患者中有三名的脑脊液中GABA浓度较低。在五例死亡病例中，五个脑区（额叶、枕叶及小脑皮质、尾状核和丘脑背内侧核）的平均GABA含量降低了30%至50%。在亨廷顿病中GABA通常会降低的脑区，其GABA含量正常。透析性脑病患者大脑皮质中的胆碱乙酰转移酶活性降低（25%至35%）。
