Lin Feng, Tang Rongzhi, Liu Sheng, Tan Yu
School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, China.
School of Energy and Environment, City University of Hong Kong, Kowloon 999077, Hong Kong, China.
Org Biomol Chem. 2025 Feb 5;23(6):1253-1291. doi: 10.1039/d4ob01654h.
Nitroso groups are widely present in biologically active compounds in medicinal chemistry, and nitroso compounds serve as important building blocks in organic chemistry and materials science. Nitrosoarenes, in particular, showcase remarkable versatility, functioning as both electrophilic and nucleophilic reagents in a broad spectrum of organic reactions, thereby holding significant relevance in organic chemistry. This review aims to provide a comprehensive overview of the latest advancements in nitrosoarene reactions spanning a decade. Special attention is given to the synthesis of products derived from nitrosoarenes and the conditions that promote these reactions, as well as the type of catalysts. The exploration covers various facets of nitrosoarene chemistry, including cyclization, reactions involving attacks at the oxygen or nitrogen terminus, dimerization, rearrangement, coordination, and other significant reactions. By delving into these diverse reaction pathways and mechanisms, this review aspires to serve as a valuable resource for researchers seeking to deepen their understanding of nitrosoarene chemistry and its applications in both fundamental and applied scientific research.
亚硝基广泛存在于药物化学中的生物活性化合物中，亚硝基化合物是有机化学和材料科学中的重要构建单元。特别是亚硝基芳烃展现出显著的多功能性，在广泛的有机反应中既作为亲电试剂又作为亲核试剂发挥作用，因此在有机化学中具有重要意义。本综述旨在全面概述近十年来亚硝基芳烃反应的最新进展。特别关注亚硝基芳烃衍生产品的合成、促进这些反应的条件以及催化剂类型。该探索涵盖亚硝基芳烃化学的各个方面，包括环化反应、涉及氧或氮端攻击的反应、二聚反应、重排反应、配位反应以及其他重要反应。通过深入研究这些不同的反应途径和机制，本综述旨在为寻求加深对亚硝基芳烃化学及其在基础和应用科学研究中的应用理解的研究人员提供有价值的资源。
