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转录组分析揭示了三阴性乳腺癌与抑郁症之间潜在的相互作用基因及免疫关系。

Transcriptomic analysis reveals potential crosstalk genes and immune relationship between triple-negative breast cancer and depression.

作者信息

Zhuo Zhili, Lu Wenping, Zhang Ling, Zhang Dongni, Cui Yongjia, Wu Xiaoqing, Mei Heting, Chang Lei, Song Qingya

机构信息

Oncology Department, China Academy of Chinese Medical Sciences Guang'anmen Hospital, No.5 Beixiange, Xicheng District, Beijing, 100053, China.

Department of pathology, China Academy of Chinese Medical Sciences Guang' anmen Hospital, Beijing, 100053, China.

出版信息

Discov Oncol. 2024 Dec 18;15(1):762. doi: 10.1007/s12672-024-01562-4.

DOI:10.1007/s12672-024-01562-4
PMID:39692924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11655728/
Abstract

TNBC, the most aggressive form of breast cancer, lacks accurate and effective therapeutic targets. Immunotherapy presents a promising approach for addressing TNBC. Anxiety and depression are frequently concurrent symptoms in TNBC patients. MDD affects the tumor immune microenvironment of TNBC, with its characteristic genes affecting the pathophysiology of MDD and potentially increasing the risk of TNBC recurrence and metastasis. This study reveals significant differences in T lymphocyte infiltration between high-risk and low-risk TNBC groups based on MDD feature genes. This finding aids in identifying TNBC patients who may benefit from immunotherapy, providing new insights for future TNBC immunotherapy strategies. Our aim is to identify MDD-related genes involved in the pathogenesis of TNBC and to provide predictive biomarkers for TNBC immunotherapy.

摘要

三阴性乳腺癌（TNBC）是最具侵袭性的乳腺癌形式，缺乏准确有效的治疗靶点。免疫疗法为治疗TNBC提供了一种有前景的方法。焦虑和抑郁是TNBC患者常见的并发症状。重度抑郁症（MDD）影响TNBC的肿瘤免疫微环境，其特征基因影响MDD的病理生理学，并可能增加TNBC复发和转移的风险。本研究揭示了基于MDD特征基因的高危和低危TNBC组之间T淋巴细胞浸润存在显著差异。这一发现有助于识别可能从免疫疗法中获益的TNBC患者，为未来TNBC免疫治疗策略提供新的见解。我们的目标是识别参与TNBC发病机制的MDD相关基因，并为TNBC免疫治疗提供预测性生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/9982f70f79eb/12672_2024_1562_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/06a4e8ccd69c/12672_2024_1562_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/90d60e5ee38c/12672_2024_1562_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/9982f70f79eb/12672_2024_1562_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/06a4e8ccd69c/12672_2024_1562_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/2a13899581bb/12672_2024_1562_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/92e2c6b7ddcb/12672_2024_1562_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/a7ad0aa156c1/12672_2024_1562_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/1eb8eae65804/12672_2024_1562_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/471722e63586/12672_2024_1562_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/90d60e5ee38c/12672_2024_1562_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29af/11655728/9982f70f79eb/12672_2024_1562_Fig8_HTML.jpg

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本文引用的文献

1
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.2022 年全球癌症统计数据：全球 185 个国家和地区 36 种癌症的发病率和死亡率全球估计数。
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Correlation between immune-related genes and depression-like features in an animal model and in humans.免疫相关基因与动物模型和人类抑郁特征的相关性。
Brain Behav Immun. 2023 Oct;113:29-43. doi: 10.1016/j.bbi.2023.06.017. Epub 2023 Jun 26.
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Immunotherapy in Early-Stage Triple-Negative Breast Cancer: Where Are We Now and Where Are We Headed?
早期三阴性乳腺癌的免疫治疗：我们现在在哪里，我们的目标在哪里？
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Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression.星形胶质细胞功能障碍导致抑郁症患者静息态功能连接异常。
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Pathogenesis of Triple-Negative Breast Cancer.三阴性乳腺癌的发病机制。
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Deep learning in cancer diagnosis, prognosis and treatment selection.深度学习在癌症诊断、预后和治疗选择中的应用。
Genome Med. 2021 Sep 27;13(1):152. doi: 10.1186/s13073-021-00968-x.
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Landscape of Immune Microenvironment Under Immune Cell Infiltration Pattern in Breast Cancer.乳腺癌免疫浸润模式下的免疫微环境景观。
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