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两例罕见的布鲁氏菌性心内膜炎和心肌心包炎病例:诊断面临的挑战

Two rare cases of Brucella-induced endocarditis and myopericarditis: challenges in diagnosis.

作者信息

Šačić Dalila, Petrović Olga, Ivanović Branislava

机构信息

Clinic for Cardiology, University Clinical Center of Serbia, Koste Todorovića 8, 11000, Belgrade, Serbia.

出版信息

J Infect Dev Ctries. 2024 Nov 30;18(11):1782-1786. doi: 10.3855/jidc.19517.

Abstract

INTRODUCTION

Brucellosis is one of the most common zoonotic infections in the world. Cardiac complications of the disease are usually in the form of endocarditis, and, to a lesser extent, in the form of myopericarditis.

CASE

We report the case of a 34-year-old female admitted with signs of fever, nausea, and headache. The patient came from Libya, where she drank unpasteurized milk. Whright-Coombs test and blood confirmed Brucella species infection, while transoesophagal echocardiogram revealed a thrombotic mass on the tricuspid valve that required cardiac surgery and antibiotic treatment, leading to complete recovery. The second case was a 37-years-old male admitted with suspected acute coronary syndrome, where further diagnostics excluded occlusions of coronary arteries and found Brucella species infection and signs of myocardial and pericardial involvement that reacted well on treatment (combination of doxycycline and rifampicin).

DISCUSSION

Brucellosis is commonly seen in people working with farm animals or using unpasteurized milk but is still often misdiagnosed.

CONCLUSIONS

Tricuspid valve endocarditis, as well as isolated myopericarditis, are rare complications of Brucellosis, which can be fatal if not diagnosed and treated on time.

摘要

引言

布鲁氏菌病是世界上最常见的人畜共患感染病之一。该疾病的心脏并发症通常表现为心内膜炎,在较小程度上表现为心肌心包炎。

病例

我们报告了一例34岁女性患者,其因发热、恶心和头痛症状入院。该患者来自利比亚,在当地饮用了未经巴氏杀菌的牛奶。wright - Coombs试验和血液检查确诊为布鲁氏菌属感染,而经食管超声心动图显示三尖瓣上有血栓形成,需要进行心脏手术并接受抗生素治疗,最终完全康复。第二例是一名37岁男性,因疑似急性冠状动脉综合征入院,进一步诊断排除了冠状动脉阻塞,发现有布鲁氏菌属感染以及心肌和心包受累迹象,经治疗(强力霉素和利福平联合使用)后反应良好。

讨论

布鲁氏菌病常见于从事家畜养殖工作或饮用未经巴氏杀菌牛奶的人群,但仍常被误诊。

结论

三尖瓣心内膜炎以及孤立性心肌心包炎是布鲁氏菌病罕见的并发症,如果不及时诊断和治疗可能会致命。

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