Endothelial Cell TRPV4 Channels Turn to the Dark Side During Hypertension.
作者信息
Mata-Daboin Alejandro, Jaggar Jonathan H
机构信息
Department of Physiology, University of Tennessee Health Science Center, Memphis.
出版信息
Hypertension. 2025 Jan;82(1):69-71. doi: 10.1161/HYPERTENSIONAHA.124.24124. Epub 2024 Dec 18.
Abstract
摘要
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本文引用的文献
1
Increased TRPV4 Channel Expression Enhances and Impairs Blood Vessel Function in Hypertension.TRPV4通道表达增加在高血压中增强并损害血管功能。
Hypertension. 2025 Jan;82(1):57-68. doi: 10.1161/HYPERTENSIONAHA.124.23092. Epub 2024 Oct 23.
2
Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure.血管扩张剂激活内皮细胞中的阴离子通道 TMEM16A，从而降低血压。
Sci Signal. 2023 Nov 14;16(811):eadh9399. doi: 10.1126/scisignal.adh9399.
3
Novel Smooth Muscle Ca-Signaling Nanodomains in Blood Pressure Regulation.新型平滑肌钙信号纳米域在血压调节中的作用。
Circulation. 2022 Aug 16;146(7):548-564. doi: 10.1161/CIRCULATIONAHA.121.058607. Epub 2022 Jun 27.
4
Endothelial TRPV4 channels modulate vascular tone by Ca -induced Ca release at inositol 1,4,5-trisphosphate receptors.内皮细胞 TRPV4 通道通过肌醇 1,4,5-三磷酸受体的 Ca2+诱导的 Ca2+释放来调节血管张力。
Br J Pharmacol. 2019 Sep;176(17):3297-3317. doi: 10.1111/bph.14762. Epub 2019 Jul 24.
5
Downregulation of endothelial transient receptor potential vanilloid type 4 channel underlines impaired endothelial nitric oxide-mediated relaxation in the mesenteric arteries of hypertensive rats.下调内皮瞬态感受器电位香草酸亚型 4 通道可导致高血压大鼠肠系膜动脉内皮一氧化氮介导的舒张功能障碍。
Physiol Res. 2019 Apr 30;68(2):219-231. doi: 10.33549/physiolres.933952. Epub 2019 Jan 10.
6
Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension.内皮瞬时受体电位香草酸亚型4通道下调及小电导钙激活钾通道下调是高血压患者内皮依赖性超极化受损的基础。
Hypertension. 2017 Jan;69(1):143-153. doi: 10.1161/HYPERTENSIONAHA.116.07110. Epub 2016 Nov 21.
7
Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium.高血糖和糖尿病下调视网膜微血管内皮细胞中TRPV4通道的功能表达。
PLoS One. 2015 Jun 5;10(6):e0128359. doi: 10.1371/journal.pone.0128359. eCollection 2015.
8
Transient receptor potential channels in the vasculature.脉管系统中的瞬时受体电位通道。
Physiol Rev. 2015 Apr;95(2):645-90. doi: 10.1152/physrev.00026.2014.
9
Characterization of blood pressure and endothelial function in TRPV4-deficient mice with l-NAME- and angiotensin II-induced hypertension.L-硝基精氨酸甲酯（L-NAME）和血管紧张素II诱导的高血压TRPV4基因敲除小鼠的血压和内皮功能特征
Physiol Rep. 2014 Jan 13;2(1):e00199. doi: 10.1002/phy2.199. eCollection 2014 Jan 1.
10
Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.内皮细胞 TRPV4 通道的基础钙信号调节血管功能。
Science. 2012 May 4;336(6081):597-601. doi: 10.1126/science.1216283.
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