骨骼干细胞：骨科病理学与组织修复的基础
Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair.
作者信息
Cong Ting, Morse Kyle W, Sosa Branden R, Lane Joseph M, Rodeo Scott A, Greenblatt Matthew B
机构信息
Department of Orthopaedic Surgery, UPMC Sports Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Department of Orthopedic Surgery, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.
出版信息
J Bone Joint Surg Am. 2025 Feb 19;107(4):418-426. doi: 10.2106/JBJS.24.00905. Epub 2024 Dec 18.
Abstract
➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.
摘要
➢ 骨骼干细胞（SSCs）持续补充成熟细胞群体以维持骨骼内稳态。
➢ 骨骼干细胞通过自我更新进行再填充，具有多谱系分化潜能，且在体内寿命较长。
➢ 骨骼干细胞表达特定的细胞表面标志物组合，这些标志物反映了它们的谱系特征。
➢ 骨骼干细胞适应其解剖学环境，以支持骨骼行为和病理学的区域差异。
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2
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3
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4
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