Department of Orthopedics, Fujian Clinical Research Center for Spinal Nerve and Joint Diseases, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.
Front Public Health. 2022 Sep 26;10:1021818. doi: 10.3389/fpubh.2022.1021818. eCollection 2022.
Bibliometric analysis and visualization tools were used to determine the development trend of mesenchymal stem cells (MSCs) in orthopedics in the past 20 years, so as to guide researchers to explore new directions and hotspots in the field in the future.
In the Web of Science Core Collection, all articles about the application of MSCs in orthopedics from 2002 to 2021 were searched. The qualitative and quantitative analysis was performed based on Web of Science and CiteSpace software.
A total of 2,207 articles were retrieved. After excluding non-article articles such as review and letter and non-English language articles, 1,489 articles were finally included. Over the past 2 decades, the number of publications on the application of MSCs in orthopedic diseases increased. Among them, the United States, China, Japan and the United Kingdom have made significant contributions in this field. The most productive institution was Shanghai Jiao Tong University. published the largest number of publications. The journal with the highest citation frequency was . The authors with the highest output and the highest citation frequency on average were Rochy S. Tuan and Scott A. Rodeo, respectively. "Mesenchymal stem cell", "" and "Differentiation" were the top three keywords that appeared. From the keyword analysis, the current research trend indicates that the primary research hotspots of MSCs in orthopedics are the source of MSCs, experiments and the differentiation of MSCs into bone and cartilage. The frontiers of this field are the combination of MSCs and platelet-rich plasma (PRP), the treatment of knee diseases such as osteoarthritis, osteogenic differentiation, and the application of biological scaffolds combined with MSCs.
Over the past 2 decades, the application of MSCs in orthopedic diseases has received increasing attention. Our bibliometric analysis results provide valuable information and research trends for researchers in the field to understand the basic knowledge of the field, identify current research hotspots, potential collaborators, and future research frontiers.
本研究运用文献计量分析与可视化工具，分析过去 20 年骨科领域间充质干细胞（MSCs）的发展趋势，旨在为未来的研究者提供新的方向和热点。
在 Web of Science 核心合集数据库中，检索 2002 年至 2021 年关于 MSCs 在骨科应用的所有文章，基于 Web of Science 和 CiteSpace 软件进行定性和定量分析。
共检索到 2207 篇文章，排除非文章类如综述和信件以及非英文文献后，最终纳入 1489 篇文章。在过去的 20 年中，MSCs 在骨科疾病中的应用研究呈增长趋势。其中，美国、中国、日本和英国在该领域贡献最大。在机构合作方面，上海交通大学发文量最多。在作者合作方面，Rochy S. Tuan 和 Scott A. Rodeo 发文量和被引频次均较高。发文量最高的期刊是 ，被引频次最高的期刊是 。出现频次最高的前三个关键词是“间充质干细胞”“分化”和“骨关节炎”。从关键词分析来看，目前的研究热点主要集中在间充质干细胞的来源、实验和向成骨和成软骨分化等方面。该领域的前沿研究方向是间充质干细胞与富血小板血浆（PRP）的结合、骨关节炎等膝关节疾病的治疗、成骨分化以及生物支架与间充质干细胞联合应用等。
过去 20 年，MSCs 在骨科疾病中的应用受到越来越多的关注。本研究的文献计量分析结果为该领域的研究人员提供了有价值的信息和研究趋势，有助于他们了解该领域的基础知识，识别当前的研究热点、潜在的合作对象和未来的研究前沿。
