Pollard M, Luckert P H
Prostate. 1985;6(1):1-5. doi: 10.1002/pros.2990060102.
Germfree (GF) Lobund strain Wistar (LW) rats, fed vegetable diet L-485, have developed prostate adenocarcinomas spontaneously (10% incidence) at average age 34 months. Conventional LW rats, implanted with testosterone at age 4 months, developed a higher incidence of prostate cancer after an average interval of 14 months: 24% had developed gross tumors, and 40% when it included microscopic tumors. Preliminary results indicate that testosterone-treated LW rats that were fed the same diet, which was supplemented with corn oil up to 20% fat, developed prostate cancer after intervals of 6-12 months. Aged GF Sprague-Dawley (SD) rats have not developed prostate cancer spontaneously. Conventional SD rats fed diet L-485 and treated with testosterone developed only prostatitis. Experimental designs should consider genetic susceptibility as a basic prerequisite for studies on experimental prostate cancer.
无菌（GF）的洛本德品系Wistar（LW）大鼠，喂食L - 485蔬菜饮食，在平均34个月龄时自发发生前列腺腺癌（发病率为10%）。4个月龄时植入睾酮的普通LW大鼠，平均间隔14个月后前列腺癌发病率更高：24%出现肉眼可见肿瘤，若包括微小肿瘤则为40%。初步结果表明，喂食相同饮食（脂肪含量补充至20%的玉米油）并经睾酮处理的LW大鼠，在6 - 12个月的间隔后发生前列腺癌。老龄GF斯普拉格 - 道利（SD）大鼠未自发发生前列腺癌。喂食L - 485饮食并经睾酮处理的普通SD大鼠仅发生前列腺炎。实验设计应将遗传易感性视为实验性前列腺癌研究的基本前提。
