17β-雌二醇对去势大鼠前列腺上皮细胞超微结构及锌亚细胞分布的影响

The effects of estradiol-17 beta on the ultrastructure and subcellular distribution of zinc in the prostatic epithelium of castrated rats.

作者信息

Timms B G, Chandler J A

出版信息

Prostate. 1985;6(1):61-79. doi: 10.1002/pros.2990060108.

Abstract

Male Sprague-Dawley rats, previously castrated for a 7-day period, were maintained on either a low or high dose of estradiol-17 beta for 3 days. Some areas of the prostatic epithelium in the lateral lobe exhibited the ultrastructural characteristics of the untreated, intact animals in response to the small dose of estrogen. The ventral lobe by comparison was not similarly affected. This stimulation in the lateral prostate was not reflected by comparable changes in the subcellular distribution of zinc.

摘要

先前已去势7天的雄性斯普拉格-道利大鼠，分别给予低剂量或高剂量的17β-雌二醇，持续3天。外侧叶前列腺上皮的一些区域在小剂量雌激素作用下，呈现出未处理的完整动物的超微结构特征。相比之下，腹侧叶未受到类似影响。外侧前列腺的这种刺激并未在锌的亚细胞分布的相应变化中体现出来。