Battersby S, Chandler J A, Morton M S
Urol Res. 1982;10(3):123-30. doi: 10.1007/BF00255954.
The effects of cadmium and nickel chloride, administered in drinking water at 5 and 50 ppm, on the rat prostate are described. Zinc concentrations in the two lobes of the gland were unaffected by the metals and no consistent changes were observed at the subcellular level by X-ray microanalysis. The ultrastructural appearance of the prostate gland in rats of varying ages was unaltered following cadmium administration at those levels, while plasma testosterone concentrations did not differ significantly in cadmium treated animals. Low levels of cadmium (less than 5 ppm) were accumulated by the ventral lobe of the prostate, although the metal was not detectable subcellularly. The results are discussed in relation to human prostatic carcinoma.
描述了以5 ppm和50 ppm的浓度通过饮用水给予大鼠镉和氯化镍后对大鼠前列腺的影响。前列腺两叶中的锌浓度不受这些金属的影响，并且通过X射线微分析在亚细胞水平未观察到一致的变化。在以这些水平给予镉后，不同年龄大鼠前列腺的超微结构外观未改变，而镉处理动物的血浆睾酮浓度没有显著差异。前列腺腹叶积累了低水平的镉（低于5 ppm），尽管在亚细胞水平未检测到该金属。结合人类前列腺癌对结果进行了讨论。
