Shi Pengfei, Fang Jianbang, Lou Chunyang
Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
Psychiatry Res. 2025 Feb;344:116328. doi: 10.1016/j.psychres.2024.116328. Epub 2024 Dec 15.
The relationship between the triglyceride glucose (TyG) index and the incidence of depression in populations with diabetes or pre-diabetes remains unclear. This study aims to investigate the association between the TyG index and depression incidence in diabetic/pre-diabetic populations.
Data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES) were analyzed. After adjustment for confounders, multivariate logistic regression models were fitted to investigate the association between TyG index and depression incidence. Restricted cubic splines (RCS), subgroup analysis, interaction analysis, and mediation analysis were also constructed.
A total of 8,970 participants with diabetes or pre-diabetes were enrolled. The linear positive association between TyG index and the incidence of depression was observed. Insulin resistance partly mediates this association in mediation analysis. There is a U-shape association between TyG index and the incidence of depression in diabetic/pre-diabetic populations whose ethnicity is Other Hispanic (p for nonlinearity =0.0237). Subgroup analysis evaluated the robustness of our findings and interaction analysis showed that this association can be modified by race/ethnicity.
There is a linear positive association between the TyG index and the incidence of depression in populations with diabetes or pre-diabetes.
甘油三酯葡萄糖（TyG）指数与糖尿病或糖尿病前期人群抑郁症发病率之间的关系尚不清楚。本研究旨在探讨糖尿病/糖尿病前期人群中TyG指数与抑郁症发病率之间的关联。
分析了2005 - 2018年美国国家健康与营养检查调查（NHANES）的数据。在对混杂因素进行调整后，采用多变量逻辑回归模型来研究TyG指数与抑郁症发病率之间的关联。还构建了受限立方样条（RCS）、亚组分析、交互作用分析和中介分析。
共纳入8970名糖尿病或糖尿病前期参与者。观察到TyG指数与抑郁症发病率之间存在线性正相关。中介分析表明胰岛素抵抗部分介导了这种关联。在种族为其他西班牙裔的糖尿病/糖尿病前期人群中，TyG指数与抑郁症发病率之间存在U型关联（非线性p值 = 0.0237）。亚组分析评估了研究结果的稳健性，交互作用分析表明这种关联会因种族/民族而改变。
糖尿病或糖尿病前期人群中，TyG指数与抑郁症发病率之间存在线性正相关。
