宿主细胞DNA甲基化标志物在宫颈筛查及宫颈上皮内瘤变管理中的临床应用：综述
Clinical indications for host-cell DNA methylation markers in cervical screening and management of cervical intraepithelial neoplasia: A review.
作者信息
Dick S, Heideman D A M, Berkhof J, Steenbergen R D M, Bleeker M C G
机构信息
Amsterdam UMC, Location Vrije Universiteit Amsterdam, Pathology, Boelelaan, 1117, Amsterdam, the Netherlands; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands.
Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands; Amsterdam UMC, Location Vrije Universiteit Amsterdam, Epidemiology and Data Science, Amsterdam, the Netherlands.
出版信息
Tumour Virus Res. 2024 Dec 16;19:200308. doi: 10.1016/j.tvr.2024.200308.
DNA methylation of host-cell genes is an epigenetic process that regulates gene expression and is associated with cervical cancer development. Studies on the natural history of cervical intraepithelial neoplasia (CIN) and the molecular alterations associated with cervical carcinogenesis led to the identification of several host-cell DNA methylation markers. Over the past years, various studies on methylation markers have shown promising results in terms of diagnostic and prognostic value to improve cervical cancer screening and management of CIN. This review provides an overview of the clinical indications of host-cell DNA methylation markers in cervical screening and management of CIN, and outlines avenues for further applications.
宿主细胞基因的DNA甲基化是一种调节基因表达的表观遗传过程，与宫颈癌的发生发展相关。对宫颈上皮内瘤变（CIN）自然史以及与宫颈癌发生相关的分子改变的研究，促成了几种宿主细胞DNA甲基化标志物的鉴定。在过去几年中，关于甲基化标志物的各种研究在改善宫颈癌筛查和CIN管理的诊断及预后价值方面显示出了有前景的结果。本综述概述了宿主细胞DNA甲基化标志物在宫颈筛查和CIN管理中的临床应用指征，并概述了进一步应用的途径。
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