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骨骼未成熟患者后交叉韧带重建或修复后生长紊乱发生率低:一项系统评价

Low rate of growth disturbance after posterior cruciate ligament reconstruction or repair in skeletally immature patients: A systematic review.

作者信息

D'Ambrosi Riccardo, Farinelli Luca, Kambhampati Srinivas B S, Sconfienza Luca M, Gitto Salvatore, Abermann Elisabeth, Fink Christian

机构信息

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, Milan, Italy.

Clinical Orthopaedics Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.

出版信息

J ISAKOS. 2025 Feb;10:100378. doi: 10.1016/j.jisako.2024.100378. Epub 2024 Dec 16.

Abstract

IMPORTANCE

The management of posterior cruciate ligament (PCL) injuries in children is complex and varies depending on the specific nature of the injury. Avulsions of the PCL can often be addressed with proximal or distal repair, whereas intrasubstance tears and cases with persistent instability generally require more extensive reconstruction. Despite the prevalence of such cases, the literature is predominantly composed of case reports, indicating a lack of comprehensive research in this area.

AIM

The purpose of this systematic review was to analyze growth disturbance in skeletally immature patients after PCL reconstruction or repair.

EVIDENCE REVIEW

A systematic review was conducted on the basis of the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The following search terms were used in the title, abstract, and keyword fields: "PCL" or "posterior cruciate ligament" AND "children" or "open physis" or "immature." The main outcome data extracted from the studies was to assess growth disturbance at a minimum 1-year follow-up after surgery.

RESULTS

A total of 34 patients, from 17 articles, were included of which 30 (88.24%) were male and 4 (11.76%) female. Mean age at surgery was 10.18 ​± ​2.88 years. The mean interval from injury to surgery was 178.9 ​± ​288.04 days. Average follow-up duration was 50.64 ​± ​22.69 months. Six studies reported on PCL reconstructions using various grafts, including autologous allografts (hamstring or tibialis anterioris), Achilles tendon allografts with bone plugs, and parental donated hamstrings allografts. Only one study reported the use of internal brace to repair PCL, whereas in all the other studies, a repair of the PCL was performed with fixation of the bone fragment (to the femur or tibia) using screws or suture. Growth disturbances (≥10 ​mm) were reported in 2 of the 13 (15.38%) patients who underwent PCL, whereas in PCL, repair was noted in 2 of the 21 patients (9.52%) (p ​= ​0.63). Only 1 patient belonging to PCL reconstruction reported a slight increase in the valgus alignment of the operated knee compared to the contralateral knee, representing medial overgrowth at the distal femur (p ​= ​0.33).

CONCLUSIONS

There is scarce literature on the risk of growth disturbance in skeletally immature patients after PCL reconstruction or repair. Nevertheless, PCL reconstruction in children indicates a low risk of growth disturbance, in particular for length leg-length discrepancy (<15%) in the mid- to long-term follow-up, and a low rate of angular deviations (<8%). This surgery remains a major challenge for orthopedic surgeons, and many unknowns remain regarding ideal grafts, technique, and time for surgery to prevent growth disturbance.

LEVEL OF EVIDENCE

Systematic review of Level IV.

REGISTRATION

PROSPERO - (CRD42024584768).

摘要

重要性

儿童后交叉韧带(PCL)损伤的处理较为复杂,且因损伤的具体性质而异。PCL撕脱伤通常可通过近端或远端修复来处理,而韧带实质内撕裂以及持续不稳定的病例通常需要更广泛的重建。尽管此类病例较为常见,但文献主要由病例报告组成,表明该领域缺乏全面的研究。

目的

本系统评价的目的是分析骨骼未成熟患者在PCL重建或修复后生长发育障碍情况。

证据综述

根据系统评价和Meta分析的首选报告项目指南进行系统评价。在标题、摘要和关键词字段中使用了以下检索词:“PCL”或“后交叉韧带”以及“儿童”或“开放骨骺”或“未成熟”。从研究中提取的主要结局数据是评估术后至少1年随访时的生长发育障碍情况。

结果

共纳入17篇文章中的34例患者,其中男性30例(88.24%),女性4例(11.76%)。手术时的平均年龄为10.18±2.88岁。从受伤到手术的平均间隔时间为178.9±288.04天。平均随访时间为50.64±22.69个月。6项研究报告了使用各种移植物进行PCL重建,包括自体移植物(腘绳肌或胫骨前肌)、带骨栓的跟腱异体移植物以及父母捐赠的腘绳肌异体移植物。只有1项研究报告使用内支架修复PCL,而在所有其他研究中,均通过使用螺钉或缝线将骨块固定(至股骨或胫骨)来修复PCL。在接受PCL重建的13例患者中有2例(15.38%)报告有生长发育障碍(≥10mm),而在PCL修复的21例患者中有2例(9.52%)出现生长发育障碍(p = 0.63)。仅1例PCL重建患者报告与对侧膝关节相比,手术侧膝关节外翻对线略有增加,表现为股骨远端内侧过度生长(p = 0.33)。

结论

关于骨骼未成熟患者在PCL重建或修复后生长发育障碍风险的文献较少。然而,儿童PCL重建显示出生长发育障碍的风险较低,特别是在中长期随访中腿长差异<15%,角度偏差率<8%。该手术对骨科医生来说仍然是一项重大挑战,关于理想的移植物、技术以及预防生长发育障碍的手术时机仍有许多未知之处。

证据级别

IV级系统评价。

注册信息

PROSPERO - (CRD42024584768)

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