Tsujimoto Hironori, Fujikura Yuji, Hamamoto Taka-Aki, Horiguchi Hiroyuki, Takahata Risa, Ishibashi Yusuke, Sugihara Takao, Kouzu Keita, Itazaki Yujiro, Fujishima Sei-Ichiro, Okamoto Koichi, Kajiwara Yoshiki, Matsukuma Susumu, Ueno Hideki
Department of Surgery, National Defense Medical College.
Department of Medical Risk Management and Infection Control, National Defense Medical College Hospital, National Defense Medical College.
Fukushima J Med Sci. 2025 Jan 18;71(1):25-34. doi: 10.5387/fms.24-00019. Epub 2024 Dec 18.
We investigated the drug resistance status of Pseudomonas aeruginosa (P. aeruginosa) focusing on its isolation sites and types of diseases. Materials and methods: A microbiological laboratory database was searched to identify all clinical cultures positive for P. aeruginosa. Clinicopathologic features and susceptibility of P. aeruginosa to any antibiotics were evaluated in patients admitted to the division of upper (Upper-GI group) or lower gastrointestinal surgery (Lower-GI group). In addition, we investigated the susceptibility of P. aeruginosa to any antibiotics based on the isolation site. Results:P. aeruginosa was frequently detected in the sputum and urine of the Upper-GI and Lower-GI groups, respectively. Among P. aeruginosa isolates from drain discharge, a significantly higher rate of resistance to imipenem, amikacin, and ciprofloxacin was observed; among P. aeruginosa isolates from wounds, a substantially higher proportion had resistance to imipenem and cefozopran in the Upper-GI group. However, there was no difference between the two groups in the drug resistance of P. aeruginosa isolated from urine, sputum, blood, and ascites. P. aeruginosa isolated from sputum showed more resistance to imipenem and ciprofloxacin than those isolated from other sites. Conclusion: There were significant differences in the drug resistance of P. aeruginosa based on the isolation sites and types of diseases. .
我们以铜绿假单胞菌的分离部位和疾病类型为重点，研究了其耐药状况。材料与方法：检索微生物实验室数据库，以确定所有铜绿假单胞菌阳性的临床培养物。对收治于上消化道手术科室（上消化道组）或下消化道手术科室（下消化道组）的患者，评估铜绿假单胞菌的临床病理特征及其对任何抗生素的敏感性。此外，我们还根据分离部位研究了铜绿假单胞菌对任何抗生素的敏感性。结果：铜绿假单胞菌分别在上消化道组和下消化道组的痰液和尿液中频繁检出。在引流液分离出的铜绿假单胞菌中，观察到对亚胺培南、阿米卡星和环丙沙星的耐药率显著更高；在上消化道组伤口分离出的铜绿假单胞菌中，对亚胺培南和头孢唑肟耐药的比例显著更高。然而，从尿液、痰液、血液和腹水中分离出的铜绿假单胞菌在两组间的耐药性无差异。从痰液中分离出的铜绿假单胞菌比亚胺培南和环丙沙星比从其他部位分离出的更耐药。结论：基于分离部位和疾病类型，铜绿假单胞菌的耐药性存在显著差异。
