Krishnan Anand, Pillai Divya, Amarchand Ritvik, Agarwal Ashish, Ahuja Vineet, Baloni Vineeta, Basu Subhra Samujjwal, Bhardwaj Pankaj, Choudhury Bikash, Chowdhury Sudipta Dhar, Dabar Deepti, Das Soumi, Deshmukh Pradeep, Devadas Krishnadas, Dhali Gopal Krishna, Gunjan Deepak, Gupta Anmol, Jain Saransh, Kedia Saurabh, Kumar Rakesh, Kumar Sanjeev, Makharia Govind K, Monga Nitika, Rungta Sumit, Saraya Anoop, Sarkar Rajib, Sharma Brij, Singh Shivendra, Sujatha Chintha, Wadhwa Nitya, Garg Pramod Kumar
All India Institute of Medical Sciences New Delhi, New Delhi, India
Translational Health Science and Technology Institute, Faridababd, Haryana, India.
BMJ Open Gastroenterol. 2024 Dec 18;11(1):e001562. doi: 10.1136/bmjgast-2024-001562.
Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India.
We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatitis in India. We plan to cover 110 000 people across 10 geographically distributed sites in 10 states of India to estimate the burden and risk factors of CP. Trained investigators will make house visits and screen for abdominal pain requiring hospitalisation or pre-diagnosed CP. The screened positive participants will be reviewed by a gastroenterologist to confirm the diagnosis of CP based on radiological imaging. For each case, four controls will be selected and data on risk factors for CP (tobacco, alcohol, family history, metabolic causes) and blood for genetic markers will be collected. Information on the cost of treatment and quality of life will be collected from patients with CP. For estimating incidence of acute pancreatitis (AP), hospital-based sentinel surveillance will be conducted in 10 districts across these 10 states. All hospitals in the district will be contacted to provide a line list of admissions due to acute abdomen including AP for 2 years. The spread of acute abdomen cases will be used to define the catchment area and estimate the denominator population. The line-listed cases with AP living in the catchment area will form the numerator to calculate the incidence. The study will provide critical information for planning pancreatitis-related services in the country.
The institutional ethics committee (IECs) at all the participating sites have given their approval for the study. All the participants whose data will be collected will be included after written informed consent. The results may be presented at national or international conferences and will be reported in peer-reviewed publications.
急性和慢性胰腺炎（CP）是胰腺的炎症性疾病，可导致局部和全身并发症。在印度，这些疾病的流行病学情况尚不为人所知。
我们描述了一项多中心研究的方案和程序，该研究旨在描绘印度胰腺炎的流行病学情况。我们计划覆盖印度10个邦中10个地理分布地点的110,000人，以评估CP的负担和风险因素。经过培训的调查人员将进行家访，并筛查需要住院治疗的腹痛或预先诊断为CP的患者。经筛查呈阳性的参与者将由胃肠病学家进行复查，以根据放射影像学确诊CP。对于每个病例，将选择4名对照，并收集CP风险因素（烟草、酒精、家族史、代谢原因）的数据以及用于基因标记的血液样本。将从CP患者那里收集治疗费用和生活质量方面的信息。为了估计急性胰腺炎（AP）的发病率，将在这10个邦的10个地区开展基于医院的哨点监测。将联系该地区的所有医院，提供一份为期2年的因急腹症（包括AP）入院的清单。急腹症病例的分布范围将用于确定集水区并估计分母人群。居住在集水区的列入清单的AP病例将作为分子来计算发病率。该研究将为该国规划与胰腺炎相关的服务提供关键信息。
所有参与地点的机构伦理委员会（IEC）均已批准该研究。所有数据将被收集的参与者在获得书面知情同意后将被纳入研究。研究结果可能在国内或国际会议上展示，并将在同行评审的出版物中报告。
