Yinzhu Ma, Yan Li, Wenqing Jiang, Yasong Du
Shanghai Mental Health Center, No. 600, Wanping South Road, Xuhui District 200030, Shanghai, China.
Shanghai Mental Health Center, No. 600, Wanping South Road, Xuhui District 200030, Shanghai, China.
Encephale. 2025 Feb;51(1):61-66. doi: 10.1016/j.encep.2024.01.004. Epub 2024 Dec 17.
To understand the clinical characteristics and risk factors of early-onset schizophrenia in children with self-injurious suicide behavior.
From March 2021 to December 2021, the clinical information of 77 inpatients with demography characteristics, family characteristics, and diseases which met the ICD-10 diagnostic criteria for "schizophrenia" in the pediatric wards of Shanghai Mental Health Center was retrospectively collected. According to whether or not there was self-injurious suicide behavior, they were divided into the self-harm and suicidal behavior group (self-harm and suicidal behavior - S) and the non-self-injurious suicide group (NS); inter-group comparison and regression analysis was performed between the two groups.
There were 51 cases (66.2%) of early-onset childhood schizophrenia patients with self-injurious suicidal behavior, verbal auditory hallucinations (94.12%) and delusion of reference (92.16%) being the main psychological symptoms. Compared with early-onset schizophrenia patients without self-injurious suicidal behavior, early-onset schizophrenia patients with self-injurious suicidal behavior had a higher incidence of delusion of reference (t=3.184, P=0.002) and command auditory hallucinations (t=2.256, P=0.027). The Eysenck Personality Questionnaire showed that the score of neuroticism was higher (F=4.139, P=0.001); the level of free tetraiodothyronine (FT4) was lower (t=-4.436, P<0.001); and logistic regression analysis showed that gender (P=0.036, OR=14.863), FT4 (P=0.011, OR=0.607) and neuroticism score (P=0.035, OR=1.073) were related to the occurrence of self-injurious suicide in children with early-onset schizophrenia.
Early-onset schizophrenia patients with self-injurious and suicidal behavior have typical psychiatric symptoms, accompanied by some characteristics associated with emotional instability. Females with low levels of FT4 and neuroticism have risk factors for suicide with self-injury in early-onset schizophrenia.
了解有自伤自杀行为的儿童早发性精神分裂症的临床特征及危险因素。
回顾性收集2021年3月至2021年12月在上海精神卫生中心儿科病房住院的77例符合ICD - 10“精神分裂症”诊断标准的具有人口学特征、家庭特征及疾病的患者临床资料。根据是否有自伤自杀行为，将其分为自伤自杀行为组（自伤自杀行为 - S）和非自伤自杀组（NS）；对两组进行组间比较及回归分析。
早发性儿童精神分裂症患者中有51例（66.2%）有自伤自杀行为，言语性幻听（94.12%）和关系妄想（92.16%）为主要精神症状。与无自伤自杀行为的早发性精神分裂症患者相比，有自伤自杀行为的早发性精神分裂症患者关系妄想发生率更高（t = 3.184，P = 0.002），命令性幻听发生率更高（t = 2.256，P = 0.027）。艾森克人格问卷显示，神经质得分更高（F = 4.139，P = 0.001）；游离甲状腺素（FT4）水平更低（t = - 4.436，P < 0.001）；逻辑回归分析显示，性别（P = 0.036，OR = 14.863）、FT4（P = 0.011，OR = 0.607）和神经质得分（P = 0.035，OR = 1.073）与早发性精神分裂症儿童自伤自杀的发生有关。
有自伤自杀行为的早发性精神分裂症患者有典型的精神症状，伴有一些与情绪不稳定相关的特征。FT4水平低且神经质的女性是早发性精神分裂症自伤自杀的危险因素。
