游离脂肪酸对极低密度脂蛋白甘油三酯肾脏代谢的影响。

Effect of free fatty acids on renal metabolism of very low density lipoprotein triglyceride.

作者信息

Trimble M E

出版信息

Ren Physiol. 1985;8(1):1-7. doi: 10.1159/000173028.

Abstract

Metabolism of very low density lipoprotein-triglyceride (VLDL-TG) was studied in the isolated perfused rat kidney (IPRK). Recirculating perfusate consisted of Krebs-Henseleit bicarbonate buffer containing 6% defatted albumin and VLDL-TG which has been labelled in vitro with 14C-tripalmitin. Results show that the IPRK catabolizes VLDL-TG. Renal removal of VLDL-TG from perfusate was impaired in the presence of 1.0 mM palmitate. A lower palmitate concentration, 0.4 mM, was without effect. It is concluded that high concentrations of circulating free fatty acids impair renal metabolism of fatty acids derived from VLDL-TG.

摘要

在离体灌注大鼠肾脏（IPRK）中研究了极低密度脂蛋白甘油三酯（VLDL-TG）的代谢。循环灌注液由含有6%脱脂白蛋白和已在体外用14C-三棕榈精标记的VLDL-TG的Krebs-Henseleit碳酸氢盐缓冲液组成。结果表明，IPRK可分解代谢VLDL-TG。在存在1.0 mM棕榈酸的情况下，从灌注液中清除VLDL-TG的能力受损。较低的棕榈酸浓度（0.4 mM）则没有影响。得出的结论是，高浓度的循环游离脂肪酸会损害源自VLDL-TG的脂肪酸的肾脏代谢。