Mao Ang, Yang Shu-Qin, Luo Ying-Juan, Ren Yan, Yan Xu, Qiu Yu-Rong, Yang Xiao
Medical Record Management Office, Chengdu Womens and Childrens Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Preventive health department, Chengdu Womens and Childrens Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
BMC Public Health. 2024 Dec 18;24(1):3404. doi: 10.1186/s12889-024-20914-x.
Obesity is a complex multisystem disease that affects almost every organ system. Studying the early determinants of obesity and implementing targeted interventions have positive implications for promoting long-term health. Therefore, this study was to evaluate the impact of maternal pre-pregnancy overweight or obesity, weight gain rate (WGR) during the second and third trimesters, infant birth weight (IBW) and BMI trajectory group (BMI-TG) from 0 to 2 years on overweight or obesity in preschool children.
A retrospective cohort analysis of data obtained from a hospital was performed using chain-mediated effects to analyze the direct and indirect effects of prepregnancy body mass index (ppBMI)on preschool children's body mass index (pcBMI), and mediated by three variables: WGR, IBW and BMI-TG.
We found that the effect of ppBMI and pcBMI was significantly mediated by IBW and BMI-TG. After adjusting for confounding factors, the total effect of ppBMI on pcBMI was estimated to be 0.1965 (bootstrap 95% CI: 0.1154-0.2783), the direct effect was 0.1562 (bootstrap 95% CI: 0.0750-0.2362), and the indirect effect was 0.0403 (bootstrap 95% CI: 0.0219 ~ 0.0651). The mediating effect accounted for 20.5% of the variance, indicating that 20.5% of the impact of ppBMI on pcBMI was mediated by two mediating factors: IBW and the BMI-TG.
Maternal overweight/obesity before pregnancy had a significant impact on overweight/obesity in preschool children and was mediated by two main factors: IBW and the BMI-TG.
肥胖是一种复杂的多系统疾病，几乎影响到每个器官系统。研究肥胖的早期决定因素并实施有针对性的干预措施对促进长期健康具有积极意义。因此，本研究旨在评估孕前超重或肥胖、孕中期和孕晚期的体重增加率（WGR）、婴儿出生体重（IBW）以及0至2岁的BMI轨迹组（BMI-TG）对学龄前儿童超重或肥胖的影响。
对从一家医院获得的数据进行回顾性队列分析，采用链式中介效应分析孕前体重指数（ppBMI）对学龄前儿童体重指数（pcBMI）的直接和间接效应，并由三个变量介导：WGR、IBW和BMI-TG。
我们发现，ppBMI和pcBMI之间的效应通过IBW和BMI-TG显著介导。在调整混杂因素后，ppBMI对pcBMI的总效应估计为0.1965（自抽样95%CI：0.1154-0.2783），直接效应为0.1562（自抽样95%CI：0.0750-0.2362），间接效应为0.0403（自抽样95%CI：0.0219～0.0651）。中介效应占方差的20.5%，表明ppBMI对pcBMI的影响有20.5%由两个中介因素介导：IBW和BMI-TG。
孕前母体超重/肥胖对学龄前儿童超重/肥胖有显著影响，主要由两个因素介导：IBW和BMI-TG。
