Xiong Bingquan, Yu Wenlong, Guan Xinyi, Tian Zhuo, Zhu Min, Yang Huiping, Wang Jiaxin, Li Yingrui, Liu Bin, Wang Yufan, She Qiang
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No.74, Linjiang Road, Yuzhong District, Chongqing, 400010, China.
Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, No.74, Linjiang Road, Chongqing, 400010, China.
BMC Public Health. 2024 Dec 18;24(1):3431. doi: 10.1186/s12889-024-20899-7.
Albuminuria, a critical and sensitive indicator of vascular injury, has been linked to early kidney damage in patients with hypertension. High-quality physical activity (PA) may reduce urinary albumin excretion. Yet, the connection between PA patterns and albuminuria is still not well understood.
Albuminuria was identified as urinary albumin/creatinine ratio (ACR) > 30 mg/g. PA was assessed by a series of self-report questionnaires and grouped into inactive PA, insufficient PA, weekend warriors (WWs), and regular PA. Logistic regression was conducted to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) to explore the relationship between PA pattern and albuminuria among hypertensive adults. Subgroup and sensitivity analyses were conducted to verify the robustness of the results.
This research included 12,961 hypertensive adults (mean age: 54.31 ± 0.24 years), including 6,060 (46.76%) females and 6,901 (53.24%) males. Of them, 2,239 (17.27%) were identified with albuminuria, and 10,722 (82.73%) were without albuminuria. Logistic regression showed that WWs had a 47% lower risk of albuminuria (OR = 0.53,95%CI:0.35-0.80), and regular PA had a 32% decreased risk of albuminuria (OR = 0.68,95%CI:0.56-0.82). However, there were no differences between WWs and regular PA in reducing albuminuria among hypertensive adults. Subgroup analyses showed that these inverse associations of WWs and regular PA with albuminuria were found in hypertensive adults without diabetes.
Compared with inactive PA, both WWs and regular PA could confer the equivalent benefits on reducing albuminuria among hypertensive adults. These findings highlight the beneficial effect of PA on albuminuria and provide a proven method for those hypertensive adults with a busy lifestyle.
蛋白尿是血管损伤的关键且敏感指标，与高血压患者的早期肾脏损害有关。高质量的体育活动（PA）可能会减少尿白蛋白排泄。然而，PA模式与蛋白尿之间的联系仍未得到充分理解。
将蛋白尿定义为尿白蛋白/肌酐比值（ACR）>30mg/g。通过一系列自我报告问卷对PA进行评估，并分为不活动的PA、不足的PA、周末战士（WWs）和规律PA。进行逻辑回归以计算比值比（OR）和95%置信区间（CIs），以探讨高血压成年人中PA模式与蛋白尿之间的关系。进行亚组和敏感性分析以验证结果的稳健性。
本研究纳入了12961名高血压成年人（平均年龄：54.31±0.24岁），其中女性6060名（46.76%），男性6901名（53.24%）。其中，2239名（17.27%）被确定有蛋白尿，10722名（82.73%）没有蛋白尿。逻辑回归显示，WWs患蛋白尿的风险降低47%（OR=0.53，95%CI：0.35-0.80），规律PA患蛋白尿的风险降低32%（OR=0.68，95%CI：0.56-0.82）。然而，在降低高血压成年人蛋白尿方面，WWs和规律PA之间没有差异。亚组分析显示，在无糖尿病的高血压成年人中发现了WWs和规律PA与蛋白尿的这些负相关关系。
与不活动的PA相比，WWs和规律PA在降低高血压成年人蛋白尿方面具有同等益处。这些发现突出了PA对蛋白尿的有益作用，并为那些生活方式忙碌的高血压成年人提供了一种行之有效的方法。
