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探索和分析两个与衰老相关的基因FPR1和UCHL1及其在加重腰椎间盘突出症中的潜在分子机制。

Exploring and analyzing two aging related genes FPR1 and UCHL1 and their potential molecular mechanisms in aggravating lumbar disc herniation.

作者信息

Zhao Di, Sha Bang-Xin, Zeng Ling-Feng, Liang Gui-Hong, Huang He-Tao, Pan Jian-Ke, Liu Jun, Zhao Shuai

机构信息

Department of Orthopedics, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, 510120, China.

Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China.

出版信息

J Orthop Surg Res. 2024 Dec 19;19(1):841. doi: 10.1186/s13018-024-05257-y.

DOI:10.1186/s13018-024-05257-y
PMID:39695855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11657882/
Abstract

The aim of this research was to investigate dysregulated pivotal genes in individuals with lumbar disc herniation (LDH) to identify potential diagnostic biomarkers and treatment targets for LDH. Key aging-related genes in LDH were identified through multiple methods. Two dysregulated key genes (FPR1 and UCHL1) were finally identified, showing high diagnostic value in both training and external validation cohorts. Dysregulated expression of these hub genes established a detrimental cycle in LDH by promoting inflammatory response, immune infiltration, and aging progression. This highlights significant pathological alterations caused by these hub genes in LDH pathogenesis. The current study developed a novel genetic signature associated with aging that accurately diagnoses LDH while characterizing biological alterations in patients with this condition. And this genetic signature holds promise as an indicator to assist clinical decision-making. Moreover, identification of FPR1 and UCHL1 as pivotal genes presents potential prospects for targeted therapeutic interventions for LDH.

摘要

本研究的目的是调查腰椎间盘突出症（LDH）患者中失调的关键基因，以确定LDH潜在的诊断生物标志物和治疗靶点。通过多种方法鉴定了LDH中与衰老相关的关键基因。最终确定了两个失调的关键基因（FPR1和UCHL1），它们在训练队列和外部验证队列中均显示出较高的诊断价值。这些枢纽基因的失调表达通过促进炎症反应、免疫浸润和衰老进程，在LDH中建立了一个有害循环。这突出了这些枢纽基因在LDH发病机制中引起的显著病理改变。当前的研究开发了一种与衰老相关的新型基因特征，它能准确诊断LDH，同时表征该疾病患者的生物学改变。并且这种基因特征有望作为一种指标来协助临床决策。此外，将FPR1和UCHL1鉴定为关键基因，为LDH的靶向治疗干预提供了潜在前景。

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