Gupta Anmol, Upadhyaya Shivam, Yeung Caleb M, Ostergaard Peter J, Fogel Harold A, Cha Thomas, Schwab Joseph, Bono Chris, Hershman Stuart
Harvard Medical School, 2348Massachusetts General Hospital, Boston, MA, USA.
Global Spine J. 2020 Oct;10(7):881-887. doi: 10.1177/2192568219880822. Epub 2019 Oct 10.
Retrospective study.
In this study, we examined whether the size of a lumbar disc herniation (LDH) is predictive of the need for surgical intervention within 2 years after obtaining an initial magnetic resonance imaging (MRI) scan. We hypothesized that a fragment that occupied a larger percentage of the spinal canal would not predict which patients failed conservative management.
Using the ICD-10 code M51.26, we identified patients at a single academic institution, across the 2-year period from 2015 to 2016, who received a diagnosis of primary lumbar radicular pain, had MRI showing a disc herniation, and underwent at least 6 weeks of nonoperative management. Patients experiencing symptoms suggesting cauda equina syndrome and those with progressive motor neurological deficits were excluded from analysis, as were patients exhibiting "hard" disc herniations. Within the axial view of an MRI, the following measurements were made on AGFA-IMPACS for a given disc herniation: the length of both the canal and the herniated disc along the anterior-posterior axis, the average width of the disc within the canal; the total canal area, and the area of the disc herniation. Data analysis was conducted in SPSS and a 2-tailed reliability analysis using Cronbach's alpha as a measure of reliability was obtained.
A total of 368 patients met the inclusion and exclusion criteria for this study. Of these, 14 (3.8%) had L3-L4 herniations, 185 had L4-L5 herniations (50.3%), and 169 had L5-S1 herniations (45.9%). Overall, 336 (91.3%) patients did not undergo surgery within 1 year of the LDH diagnosis. Patients who did not receive surgery had an average herniation size that occupied 31.2% of the canal, whereas patients who received surgery had disc herniations that occupied 31.5% of the canal on average. A Cronbach's alpha of .992 was observed overall across interobserver measurements. After controlling for age, race, gender, and location of herniation through a logistic regression, it was found that the size of the herniation and the percentage of the canal that was occupied had no predictive value with regard to failure of conservative management, generating an odds ratio for surgery of 1.00.
The percentage of the spinal canal occupied by a herniated disc does not predict which patients will fail nonoperative treatment and require surgery within 2 years after undergoing a lumbar spine MRI scan.
回顾性研究。
在本研究中,我们探讨了腰椎间盘突出症(LDH)的大小是否可预测在初次进行磁共振成像(MRI)扫描后2年内进行手术干预的必要性。我们假设占据椎管较大百分比的椎间盘碎片无法预测哪些患者保守治疗失败。
使用国际疾病分类第十版(ICD - 10)编码M51.26,我们在一所学术机构中识别出2015年至2016年这2年期间被诊断为原发性腰椎神经根性疼痛、MRI显示椎间盘突出且接受了至少6周非手术治疗的患者。出现马尾综合征症状的患者、有进行性运动神经功能缺损的患者以及表现为“硬性”椎间盘突出的患者被排除在分析之外。在MRI的轴位视图中,针对给定的椎间盘突出在AGFA - IMPACS上进行以下测量:椎管和突出椎间盘沿前后轴的长度、椎管内椎间盘的平均宽度、椎管总面积以及椎间盘突出面积。数据分析在SPSS中进行,并获得了使用克朗巴哈系数(Cronbach's alpha)作为可靠性度量的双尾可靠性分析结果。
共有368例患者符合本研究的纳入和排除标准。其中,14例(3.8%)为L3 - L4椎间盘突出,185例为L4 - L5椎间盘突出(50.3%),169例为L5 - S1椎间盘突出(45.9%)。总体而言,336例(91.3%)患者在LDH诊断后1年内未接受手术。未接受手术的患者平均突出大小占椎管的31.2%,而接受手术的患者椎间盘突出平均占椎管的31.5%。观察者间测量的总体克朗巴哈系数为0.992。通过逻辑回归控制年龄、种族、性别和突出位置后,发现突出大小和椎管占据百分比对于保守治疗失败没有预测价值,手术的优势比为1.00。
椎间盘突出占据椎管的百分比不能预测哪些患者在进行腰椎MRI扫描后2年内非手术治疗会失败并需要手术。