Cao Lijun, Qi Xin, Liu Dan, Mao Xincheng, Luo Liu, Liu Mengjiang, Wen Xinyi, Cui Chunhong, Qi Jia, Xu Junmei, Cui Yulong
Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Department of Anesthesia, Guilin Hospital of the Second Xiangya Hospital, Central South University, Guilin, Guangxi, 541000, China.
BMC Anesthesiol. 2024 Dec 19;24(1):457. doi: 10.1186/s12871-024-02848-4.
The aim of this study was to explore whether continuous infusion causing lubrication can effectively alleviate pain during male urethral catheterization.
This prospective, multicenter, double-blinded study included 190 male patients scheduled for urethral catheterization. Patients were randomly allocated into four groups: Group A: the catheter was lubricated with paraffin; Group B: the catheter was lubricated with compound lidocaine gel; Group C: the pump continuously infusing with sterilized water; Group D: the pump continuously infusing with 2% lidocaine. The primary outcome was the visual analogue scale (VAS) scores. Statistical analysis system (SAS) (version 9.4) was used to perform all the statistical analyses. Significance for all results was set at P < 0.05.
The VAS of Group D was the lowest (18.90 ± 11.44), followed by the Group C (33.00 ± 11.07), and the VAS of Group A was the highest (53.98 ± 14.76). There were significant differences in VAS in Group D compared to Group A(P < 0.0001), Group B(P < 0.0001) and Group C (P < 0.0001), Group C compared to Group A (P < 0.0001) and Group B(P < 0.0001), Group B compared to Group A (P < 0.0001), indicating that patients treated with lidocaine infusion (Group D) experienced significantly less pain than did those in the other three groups.
Continuous infusion with sterilized water during catheterization is an efficient method for lubricating the urethral mucosa; furthermore, infusion with 2% lidocaine provides better analgesia as well as lubrication.
The study protocol was registered in the Chinese Clinical Trial Registry (ChiCTR2300070866) ( https://www.chictr.org.cn/showproj.html?proj=194591 ) on Apr. 25th, 2023.
本研究旨在探讨持续输注进行润滑是否能有效减轻男性导尿过程中的疼痛。
这项前瞻性、多中心、双盲研究纳入了190例计划进行导尿的男性患者。患者被随机分为四组：A组：用石蜡润滑导管；B组：用复方利多卡因凝胶润滑导管；C组：用泵持续输注无菌水；D组：用泵持续输注2%利多卡因。主要结局指标为视觉模拟评分（VAS）。采用统计分析系统（SAS）（9.4版）进行所有统计分析。所有结果的显著性设定为P < 0.05。
D组的VAS最低（18.90±11.44），其次是C组（33.00±11.07），A组的VAS最高（53.98±14.76）。D组与A组（P < 0.0001）、B组（P < 0.0001）和C组（P < 0.0001）相比，VAS存在显著差异；C组与A组（P < 0.0001）和B组（P < 0.0001）相比，VAS存在显著差异；B组与A组（P < 0.0001）相比，VAS存在显著差异，表明利多卡因输注治疗的患者（D组）比其他三组患者经历的疼痛明显更少。
导尿过程中持续输注无菌水是润滑尿道黏膜的有效方法；此外，输注2%利多卡因可提供更好的镇痛和润滑效果。
该研究方案于2023年4月25日在中国临床试验注册中心（ChiCTR2300070866）（https://www.chictr.org.cn/showproj.html?proj=194591）注册。
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