Richards A, Stather-Dunn L, Moodley J
S Afr Med J. 1985 Jan 26;67(4):145.
The death of a patient from cardiopulmonary arrest after the administration of magnesium sulphate for imminent eclampsia is reported. It has long been recognized that magnesium sulphate provides rapid control of convulsions in eclamptic patients with minimal sedative effects on both mother and fetus. However, because of the neuromuscular blocking action of magnesium and the narrow margin between therapeutic and toxic serum levels, the drug must be given with caution. A regimen for magnesium sulphate administration is advocated which allows safe and effective control of convulsions in eclampsia.
据报道，一名子痫前期患者在静脉注射硫酸镁后因心肺骤停死亡。长期以来，人们一直认为硫酸镁能迅速控制子痫患者的惊厥，对母亲和胎儿的镇静作用最小。然而，由于镁的神经肌肉阻滞作用以及治疗性血清水平与毒性血清水平之间的差距很窄，必须谨慎使用该药物。本文倡导一种硫酸镁给药方案，该方案能够安全有效地控制子痫惊厥。
