Jiang Chaoyang, Li Jiawei, Peng Haibo, Zhou Daijun, Xu Chuan, Zhang Ling, Wang Juan, Liu Bisheng, Li Dong
Department of Oncology, The General Hospital of Western Theater Command, Chengdu, China.
Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
BMC Cancer. 2024 Dec 18;24(1):1530. doi: 10.1186/s12885-024-13251-0.
The delineation of clinical target volume (CTV) base on the correlation analysis between neck node levels of OCSCC has not been reported in detail. This study analyzes the correlations between the neck node levels in 208 cases of OCSCC, and aims to provide preliminary reference for the CTV delineation in OCSCC patients.
The records of 208 OCSCC patients were retrospectively analyzed. The neck node levels were evaluated according to the 2013 updated guidelines. The Chi-square test and logistic regression model were used to analyze the correlation of each level.
The most common involved level in OCSCC is Ib (45.7%) and IIa (40.4%). Correlation analysis of OCSCC showed that nodal spread in level Ia is related to levels Ib and VIa. Level Ib is related to levels Ia, IIa, IX. Level IIa is related to levels Ib, IIb, III. Level IIb is related to levels IIa, III, Va. Level III is related to levels IIa, IIb, Va. Level Va is related to levels IIb and III. Level VIa is related to level Ia and T stage. Level IX is only related to level Ib. T stage is only related to level VIa. All the above P values are < 0.05.
The related levels can be considered as high-risk region (HRR) and the unrelated levels as low-risk region (LRR) in the radiotherapy of OCSCC patients. This study can make the CTV delineation more individualized and accurate.
基于口腔鳞状细胞癌（OCSCC）颈部淋巴结分区相关性分析来勾画临床靶区（CTV）的研究尚未详细报道。本研究分析208例OCSCC患者颈部淋巴结分区的相关性，旨在为OCSCC患者CTV的勾画提供初步参考。
回顾性分析208例OCSCC患者的病历资料。根据2013年更新指南评估颈部淋巴结分区。采用卡方检验和逻辑回归模型分析各分区的相关性。
OCSCC最常累及的分区是Ib（45.7%）和IIa（40.4%）。OCSCC的相关性分析显示，Ia区的淋巴结转移与Ib区和VIa区相关。Ib区与Ia区、IIa区、IX区相关。IIa区与Ib区、IIb区、III区相关。IIb区与IIa区、III区、Va区相关。III区与IIa区、IIb区、Va区相关。Va区与IIb区和III区相关。VIa区与Ia区和T分期相关。IX区仅与Ib区相关。T分期仅与VIa区相关。上述所有P值均<0.05。
在OCSCC患者放疗中，可将相关分区视为高风险区域（HRR），不相关分区视为低风险区域（LRR）。本研究可使CTV的勾画更具个体化和准确性。
