Jamialahmadi Tannaz, Reiner Željko, Simental-Mendia Luis E, Almahmeed Wael, Karav Sercan, Eid Ali H, Giammarile Francesco, Sahebkar Amirhossein
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Inflamm (Lond). 2024 Dec 18;21(1):52. doi: 10.1186/s12950-024-00421-x.
Pathogenesis of atherosclerosis is largely mediated by inflammatory process. Statins are lipid-lowering drugs which also have anti-inflammatory effects. 18 fluorine radiolabeled fluorodeoxyglucose (18 F-FDG) positron emission tomography-computed tomography (PET-CT) is considered to be a good indicator of arterial wall inflammation. Therefore, in this meta-analysis the role of statins on inflammatory process in the artery wall was evaluated using this method since its actual validity for this purpose is not yet well established.
PubMed, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases were searched using MESH terms and keywords. Funnel plot, Begg's rank correlation, and Egger's weighted regression tests evaluated publication bias in the meta-analysis. In cases where funnel plot asymmetry was observed, the "trim and fill" method was used to check the input of potentially missing studies.
Findings of 10 clinical trials involving 373 subjects showed a remarkable reduction of arterial wall 18 F-FDG uptake according to target-to-background ratio (TBR) index after treatment with statins. Subgroup analysis showed a significant decrease in TBR with high-intensity and non-significant reduction of TBR with low-to-moderate-intensity statin therapy.
Treatment with statins suppressed arterial wall inflammation as shown by using 18 F-FDG PET-CT.
动脉粥样硬化的发病机制很大程度上由炎症过程介导。他汀类药物是降脂药物，也具有抗炎作用。18氟放射性标记的氟脱氧葡萄糖（18F-FDG）正电子发射断层扫描-计算机断层扫描（PET-CT）被认为是动脉壁炎症的良好指标。因此，在本荟萃分析中，使用该方法评估他汀类药物对动脉壁炎症过程的作用，因为其在此目的上的实际有效性尚未得到充分证实。
使用医学主题词和关键词搜索PubMed、Scopus、科学网、临床试验.gov和谷歌学术数据库。漏斗图、Begg秩相关和Egger加权回归检验评估荟萃分析中的发表偏倚。在观察到漏斗图不对称的情况下，使用“修剪和填充”方法检查潜在缺失研究的纳入情况。
10项涉及373名受试者的临床试验结果显示，他汀类药物治疗后，根据靶本比（TBR）指数，动脉壁18F-FDG摄取显著降低。亚组分析显示，高强度他汀治疗时TBR显著降低，低至中等强度他汀治疗时TBR降低不显著。
如18F-FDG PET-CT所示，他汀类药物治疗可抑制动脉壁炎症。
