Premnath Sujatha Mahadevarao, Nanda Sunil Kumar, Ray Lopamudra, Arokiaraj Mark Chirstopher
Department of Biochemistry, Pondicherry Institute of Medical Science, Pondicherry, India.
Department of Biochemistry, CCM Government Medical College, Durg, Chhattisgarh, India.
J Lab Physicians. 2023 Apr 18;15(4):498-502. doi: 10.1055/s-0043-1768167. eCollection 2023 Dec.
Atherosclerosis mediated by inflammatory markers is the corner stone in the pathology of coronary artery disease (CAD). Hyperlipidemia, one of the risk factors is treated with statins. Statins also have a pleotropic role in reducing inflammation. Effect of statins on two inflammatory markers pentraxin 3(PTX 3) and high sensitivity C-reactive protein (hs-CRP) is explored in this study. This article estimates the levels of serum PTX 3 and hs-CRP in CAD patients with and without statin therapy and correlates the levels with low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) in CAD patients without statin therapy. This was a cross-sectional study conducted on 62 patients with CAD diagnosed by coronary angiogram. They were divided into two groups. Group I were the CAD patients on statin therapy and group II were CAD patients who never had any lipid lowering drugs irrespective of their lipid values. Serum PTX3, hs-CRP, and lipid profile were estimated in these groups. Comparison between the groups was done using Student's -test and correlation analyzed using Pearson's correlation. Serum PTX 3 and hs-CRP levels were higher than the reference range in both the groups. But group I showed significantly low PTX 3 levels ( -value = 0.032) compared with group II. There was a significant positive relationship between PTX 3 and LDL-c ( = 0.003) in group II. CAD patients on statin therapy have lower vessel wall inflammation compared with patients without statin therapy.
由炎症标志物介导的动脉粥样硬化是冠状动脉疾病（CAD）病理学的基石。高脂血症作为危险因素之一，可通过他汀类药物进行治疗。他汀类药物在减轻炎症方面也具有多效性作用。本研究探讨了他汀类药物对两种炎症标志物——五聚体3（PTX 3）和高敏C反应蛋白（hs-CRP）的影响。
本文评估了接受他汀类药物治疗和未接受他汀类药物治疗的CAD患者血清PTX 3和hs-CRP水平，并将未接受他汀类药物治疗的CAD患者的这些水平与低密度脂蛋白胆固醇（LDL-c）和高密度脂蛋白胆固醇（HDL-c）进行关联分析。
这是一项对62例经冠状动脉造影诊断为CAD的患者进行的横断面研究。他们被分为两组。第一组是接受他汀类药物治疗的CAD患者，第二组是无论血脂水平如何从未服用过任何降脂药物的CAD患者。对这些组进行血清PTX3、hs-CRP和血脂谱的评估。组间比较采用Student's t检验，相关性分析采用Pearson相关性分析。
两组患者的血清PTX 3和hs-CRP水平均高于参考范围。但与第二组相比，第一组的PTX 3水平显著较低（P值 = 0.032）。在第二组中，PTX 3与LDL-c之间存在显著正相关（P = 0.003）。
与未接受他汀类药物治疗的患者相比，接受他汀类药物治疗的CAD患者血管壁炎症较轻。
