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lncRNA ST7-AS1与食管癌进展及治疗靶点的相关性研究

Research on Correlations of lncRNA ST7-AS1 with Progression and Therapeutic Targets of Esophageal Cancer.

作者信息

Lin Xiao, Sun Sijia, Zhang JiWen, Cai Yan, Cheng Quan

机构信息

Department of Gastroenterology, Taizhou Integrated Chinese and Western Medicine Hospital, Wenling, China.

Department of Gastroenterology, Huashan Hospital Fudan University, Shanghai, China.

出版信息

Turk J Gastroenterol. 2024 Dec 16;36(2):82-88. doi: 10.5152/tjg.2024.24260.

DOI:10.5152/tjg.2024.24260
PMID:39696960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11843310/
Abstract

Esophageal cancer is a highly prevalent gastrointestinal tumor in China, resulting in a significant number of deaths annually. In this paper, we investigated the regulatory role and therapeutic potential of aberrant ST7-AS1 expression in esophageal cancer. The presence of ST7-AS1 in 125 esophageal cancer tissues was identified through RT-qPCR assays. The application of Kaplan-Meier to evaluate survival rates in patients with esophageal cancer. Cell activity was assessed by both CCK-8 and Transwell assays. The luciferase activity assay verified the association of ST7-AS1 with miR-4262. ST7-AS1 expression in esophageal cancer was noticeably overexpressed compared to the control group. Patients with upregulated ST7-AS1 had shorter survival rates. Silencing ST7-AS1 reduced the proliferation level of esophageal cancer cells, as did the migration and invasion levels. Mechanistically, ST7-AS1 acted as a sponge for miR-4262, affecting the progression of esophageal cancer. This was negatively correlated with ST7-AS1. Moreover, the miR-4262 inhibitor negated the inhibitory effect of silencing ST7-AS1 on cells. Knockdown of ST7-AS1 may alleviate tumor progression by targeting miR-4262, indicating that ST7-AS1 is anticipated to serve as a therapeutic biomarker for patients with esophageal cancer.

摘要

食管癌是中国一种高度常见的胃肠道肿瘤，每年导致大量死亡。在本文中，我们研究了异常的ST7-AS1表达在食管癌中的调控作用和治疗潜力。通过RT-qPCR检测确定了125例食管癌组织中ST7-AS1的存在情况。应用Kaplan-Meier法评估食管癌患者的生存率。通过CCK-8和Transwell检测评估细胞活性。荧光素酶活性检测验证了ST7-AS1与miR-4262的关联。与对照组相比，食管癌中ST7-AS1表达明显上调。ST7-AS1上调的患者生存率较短。沉默ST7-AS1降低了食管癌细胞的增殖水平，迁移和侵袭水平也降低。机制上，ST7-AS1作为miR-4262的海绵，影响食管癌的进展。这与ST7-AS1呈负相关。此外，miR-4262抑制剂消除了沉默ST7-AS1对细胞的抑制作用。敲低ST7-AS1可能通过靶向miR-4262减轻肿瘤进展，表明ST7-AS1有望成为食管癌患者的治疗生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/9eb2d705ef33/tjg-36-2-82_f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/d9e52962c46c/tjg-36-2-82_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/0b1c96a353d9/tjg-36-2-82_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/f279639ea2f9/tjg-36-2-82_f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/82c3259482b4/tjg-36-2-82_f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/9eb2d705ef33/tjg-36-2-82_f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/d9e52962c46c/tjg-36-2-82_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/0b1c96a353d9/tjg-36-2-82_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/f279639ea2f9/tjg-36-2-82_f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/82c3259482b4/tjg-36-2-82_f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/278a/11843310/9eb2d705ef33/tjg-36-2-82_f005.jpg

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Cell Mol Life Sci. 2024 Mar 8;81(1):121. doi: 10.1007/s00018-024-05172-9.
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A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma.PDIA3P1 与 OCT4 之间的正反馈促进食管鳞癌细胞的癌症干细胞特性。
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A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma.
Wnt 诱导的长非编码 RNA-DGCR5 剪接开关驱动食管鳞状细胞癌中的促肿瘤炎症。
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Long Noncoding RNAs in the Prediction of Survival of Patients with Digestive Cancers.长链非编码 RNA 在预测消化系统癌症患者生存中的作用。
Turk J Gastroenterol. 2023 Jan;34(1):19-25. doi: 10.5152/tjg.2022.22017.
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