Sağlam Osman, Harputluoğlu Muhsin Murat Muhip, Bilgiç Yılmaz, Yılmaz Sezai, Yağın Fatma Hilal, Efe Cumali
Department of Gastroenterology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Türkiye.
Department of Gastroenterology, İnonu University Faculty of Medicine, Malatya, Türkiye.
Turk J Gastroenterol. 2024 Dec 16;36(3):145-151. doi: 10.5152/tjg.2024.24464.
BACKGROUND/AIMS: We analyzed the frequency of complications and survival rates in patients with autoimmune hepatitis (AIH) who underwent liver transplantation at a high-volume transplant center.
Patients who underwent transplantation for AIH at the İnönü University Liver Transplantation Institute between January 2002 and December 2021 were included. Patients with a confirmed diagnosis of AIH, without concomitant chronic liver disease, were included in the study.
We included 51 patients (31 female) with a median age of 38.5 years (18-65 years). The 12-month and 60-month survival rates were 86.3% and 80.9%, respectively. During a median 2.22 years follow-up, 9 patients died. Six patients died due to systemic infection, 1 due to biliary complications, and 2 patients due to graft rejection. Autoimmune hepatitis recurrence developed in 6 (11%) patients. Overall, biliary complications developed in 56% (28/51) of patients following liver transplantation, and graft rejection occurred in 22% (11/51) of patients.
Our results suggest that the outcome of AIH following liver transplantation is good, with a survival rate of up to 80%. Posttransplant biliary complications are common; therefore, close follow-up is necessary.
背景/目的：我们分析了在一家大型移植中心接受肝移植的自身免疫性肝炎（AIH）患者的并发症发生率和生存率。
纳入2002年1月至2021年12月期间在伊诺努大学肝移植研究所因AIH接受移植的患者。确诊为AIH且无合并慢性肝病的患者纳入本研究。
我们纳入了51例患者（31例女性），中位年龄为38.5岁（18 - 65岁）。12个月和60个月的生存率分别为86.3%和80.9%。在中位2.22年的随访期间，9例患者死亡。6例患者死于全身感染，1例死于胆道并发症，2例死于移植排斥反应。6例（11%）患者发生了自身免疫性肝炎复发。总体而言，56%（28/51）的患者肝移植后出现胆道并发症，22%（11/51）的患者发生移植排斥反应。
我们的结果表明，肝移植后AIH的预后良好，生存率高达80%。移植后胆道并发症很常见；因此，密切随访是必要的。
