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肝移植患者社会经济状况及其他影响患者-移植物存活因素的分析

Analysis of socioeconomic status and other factors affecting patient-graft survival in patients undergoing liver transplantation.

作者信息

Onder Arif Hakan, Bengi Goksel, Ozbilgin Mucahit, Unek Tarkan, Astarcioglu Ibrahim, Akarsu Mesut

机构信息

Department of Internal Medicine, Dokuz Eylul University, Izmir, Turke.

Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey.

出版信息

Hepatol Forum. 2020 Jan 20;1(1):25-36. doi: 10.14744/hf.2020.0003. eCollection 2020 Jan.

DOI:10.14744/hf.2020.0003
PMID:35949664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9344369/
Abstract

BACKGROUND AND AIM

Liver transplantation is performed in increasing numbers due to advances in surgical techniques and the introduction of diverse immunosuppressive drugs. The present study aims to analyze the effects of socioeconomic status and education level on patient and graft survival, in addition to all these factors.

MATERIAL AND METHODS

All patients aged 18 years and above who underwent consecutive liver transplantation at the Liver Transplantation Unit of Department of General Surgery at the Dokuz Eylül University Hospital and whose data were available were included in this study.

RESULTS

Incompliance was noted in 68.3% of the 278 patients. On the other hand, patient compliance did not have a significant effect on graft and patient survival. However, decreased levels in the parameters, such as education status, vocational status and socioeconomic status, were found to be correlated with patient compliance. A significant correlation was not found between these factors and patient and graft survival.

CONCLUSION

Although a direct effect of socioeconomic status on patient and graft survival could not be shown the significant association of vocational status and education status which determine socioeconomic level with parameters other than patient and graft survival may affect the success of liver transplants.

摘要

背景与目的

由于手术技术的进步以及多种免疫抑制药物的引入,肝移植的实施数量不断增加。本研究旨在除分析所有这些因素外,还分析社会经济地位和教育水平对患者及移植物存活的影响。

材料与方法

本研究纳入了所有年龄在18岁及以上、在多库兹艾吕尔大学医院普通外科肝移植科接受连续肝移植且数据可用的患者。

结果

278例患者中68.3%存在不依从情况。另一方面,患者依从性对移植物和患者存活没有显著影响。然而,发现教育状况、职业状况和社会经济状况等参数水平的降低与患者依从性相关。这些因素与患者及移植物存活之间未发现显著相关性。

结论

尽管未显示社会经济地位对患者及移植物存活有直接影响,但决定社会经济水平的职业状况和教育状况与患者及移植物存活以外的参数之间的显著关联可能会影响肝移植的成功率。

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本文引用的文献

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Transplantation vs resection for hepatocellular carcinoma with compensated liver function after downstaging therapy.降期治疗后肝功能代偿的肝细胞癌行肝移植与切除术的比较。
World J Gastroenterol. 2013 Jul 21;19(27):4400-8. doi: 10.3748/wjg.v19.i27.4400.
2
Who fares worse after liver transplantation? Impact of donor and recipient variables on outcome: data from a prospective study.肝移植后谁的情况更糟?供体和受者变量对结局的影响:一项前瞻性研究的数据。
Transplantation. 2013 Jun 27;95(12):1528-34. doi: 10.1097/TP.0b013e318292827f.
3
Impact of recipients' socio-economic status on patient and graft survival after liver transplantation: the IsMeTT experience.
肝移植后受者社会经济地位对患者和移植物存活的影响:IsMeTT 经验。
Dig Liver Dis. 2011 Nov;43(11):893-8. doi: 10.1016/j.dld.2011.06.017. Epub 2011 Jul 27.
4
Modified Charlson Comorbidity Index in predicting early mortality after liver transplantation.改良Charlson合并症指数在预测肝移植术后早期死亡率中的应用
Transplant Proc. 2009 Oct;41(8):3117-8. doi: 10.1016/j.transproceed.2009.07.097.
5
Interventions to improve medication-adherence after transplantation: a systematic review.改善移植后药物依从性的干预措施:一项系统综述。
Transpl Int. 2009 Aug;22(8):780-97. doi: 10.1111/j.1432-2277.2009.00881.x. Epub 2009 Apr 6.
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BK virus in liver transplant recipients: a prospective study.肝移植受者中的BK病毒:一项前瞻性研究。
Transplant Proc. 2009 Apr;41(3):1033-7. doi: 10.1016/j.transproceed.2009.02.021.
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Post-liver transplantation medical complications.肝移植术后医学并发症
Ann Hepatol. 2006 Apr-Jun;5(2):77-85.
8
Liver transplantation in Italy: analysis of risk factors associated with graft outcome.
Prog Transplant. 2006 Mar;16(1):57-64. doi: 10.1177/152692480601600112.
9
Obesity increases mortality in liver transplantation--the Danish experience.肥胖增加肝移植死亡率——丹麦的经验。
Transpl Int. 2005 Nov;18(11):1231-5. doi: 10.1111/j.1432-2277.2005.00206.x.
10
AASLD practice guidelines: Evaluation of the patient for liver transplantation.美国肝病研究学会实践指南:肝移植患者评估
Hepatology. 2005 Jun;41(6):1407-32. doi: 10.1002/hep.20704.