Zhang Jiangming, Qi Minjun, Ma Lumei, Liu Dongmei
The First Clinical Medical College of Gansu University of Traditional Chinese Medicine, Lanzhou 730030, Gansu, China.
Department of Critical Care Medicine, the 940 Hospital of Joint Logistic Support Force of PLA, Lanzhou 730050, Gansu, China.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2024 Nov;36(11):1216-1220. doi: 10.3760/cma.j.cn121430-20231018-00883.
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-associated acute kidney injury (SA-AKI) is a common organ dysfunction of sepsis, and its incidence and mortality are increasing,which brings heavy economic burden to patients and society. Early diagnosis and effective intervention can block the occurrence and progression of SA-AKI effectively, improve prognosis, and reduce medical costs. Diagnosis on SA-AKI relies on urine volume and serum creatinine, which has the disadvantages of being easily disturbed and delaying. The identification of biomarkers in blood and urine can facilitate diagnosis and provide targeted therapy to enhance the management of SA-AKI. This article reviews the characteristics of a variety of SA-AKI biomarkers that have been found and validated, including pre-damage biomarkers, damage biomarkers and functional biomarkers, and explore the clinical value of newly discovered biomarkers related to the diagnosis and treatment of SA-AKI, such as blood uncoupling protein 2 (UCP2), Sestrin 2 protein and pannexin 1 (PANX1), to provide reference for the early diagnosis and effective treatment of SA-AKI.
脓毒症被定义为由宿主对感染的失调反应引起的危及生命的器官功能障碍。脓毒症相关急性肾损伤（SA-AKI）是脓毒症常见的器官功能障碍，其发病率和死亡率不断上升，给患者和社会带来沉重的经济负担。早期诊断和有效干预可有效阻断SA-AKI的发生和发展，改善预后并降低医疗成本。SA-AKI的诊断依赖于尿量和血清肌酐，存在易受干扰和延误的缺点。血液和尿液中生物标志物的鉴定有助于诊断并提供靶向治疗，以加强SA-AKI的管理。本文综述了已发现并验证的多种SA-AKI生物标志物的特征，包括损伤前生物标志物、损伤生物标志物和功能生物标志物，并探讨新发现的与SA-AKI诊断和治疗相关的生物标志物（如血液解偶联蛋白2（UCP2）、Sestrin 2蛋白和泛连接蛋白1（PANX1））的临床价值，为SA-AKI的早期诊断和有效治疗提供参考。
