微小RNA在脓毒症相关性急性肾损伤中的研究进展

[Research progress of microRNAs in sepsis-associated acute kidney injury].

作者信息

Peng Wenjing, Li Guofu

机构信息

Department of Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China. Corresponding author: Li Guofu, Email:

出版信息

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2022 May;34(5):556-560. doi: 10.3760/cma.j.cn121430-20211117-01740.

DOI:10.3760/cma.j.cn121430-20211117-01740

PMID:35728863

Abstract

Sepsis is a life-threatening organ dysfunction syndrome caused by the host's maladjusted response to infection, and is one of the important causes of acute kidney injury (AKI). Sepsis-associated acute kidney injury (SA-AKI) has a high incidence, poor prognosis and high mortality. The pathogenesis of SA-AKI is very complex, and its pathogenesis has not been fully elucidated. Therefore, finding effective biomarkers for early diagnosis, treatment, disease development and prognosis of SA-AKI is an urgent clinical problem.

摘要

脓毒症是一种由宿主对感染的失调反应引起的危及生命的器官功能障碍综合征，是急性肾损伤（AKI）的重要原因之一。脓毒症相关急性肾损伤（SA-AKI）发病率高、预后差且死亡率高。SA-AKI的发病机制非常复杂，其发病机制尚未完全阐明。因此，寻找用于SA-AKI早期诊断、治疗、疾病进展及预后评估的有效生物标志物是一个亟待解决的临床问题。