Feng Xiuqin, Cao Fujun, Wu Xiangji, Xie Wenyan, Wang Ping, Jiang Hong
Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Immunol. 2024 Dec 2;15:1467602. doi: 10.3389/fimmu.2024.1467602. eCollection 2024.
The physical characteristics of the tumor microenvironment (TME) include solid stress, interstitial fluid pressure, tissue stiffness and microarchitecture. Among them, abnormal changes in tissue stiffness hinder drug delivery, inhibit infiltration of immune killer cells to the tumor site, and contribute to tumor resistance to immunotherapy. Therefore, targeting tissue stiffness to increase the infiltration of drugs and immune cells can offer a powerful support and opportunities to improve the immunotherapy efficacy in solid tumors. In this review, we discuss the mechanical properties of tumors, the impact of a stiff TME on tumor cells and immune cells, and the strategies to modulate tumor mechanics.
肿瘤微环境（TME）的物理特征包括固体应力、间质液压力、组织硬度和微观结构。其中，组织硬度的异常变化会阻碍药物递送，抑制免疫杀伤细胞向肿瘤部位的浸润，并导致肿瘤对免疫治疗产生抗性。因此，针对组织硬度来增加药物和免疫细胞的浸润，可以为提高实体瘤免疫治疗疗效提供有力支持和机会。在这篇综述中，我们讨论了肿瘤的力学特性、坚硬的肿瘤微环境对肿瘤细胞和免疫细胞的影响，以及调节肿瘤力学的策略。
