Greenwood Christopher J, Letcher Primrose, Laurance Esther, Boden Joseph M, Foulds James, Spry Elizabeth A, Kerr Jessica A, Toumbourou John W, Heerde Jessica A, Nolan Catherine, Bonomo Yvonne, Hutchinson Delyse M, Slade Tim, Aarsman Stephanie R, Olsson Craig A
Deakin University, Geelong, Australia.
Murdoch Children's Research Institute, Parkville, Australia.
JAACAP Open. 2024 Apr 19;2(4):311-322. doi: 10.1016/j.jaacop.2024.03.002. eCollection 2024 Dec.
The global impact of substance use, including cannabis, amphetamine, cocaine, ecstasy, hallucinogens, and opioids, is increasing, although the overall prevalence is low. Australia and New Zealand are among the few regions of the world in which use (typically illicit) of these classes of substances remains within the top 10 causes of disease burden. The period of adolescence and young adulthood, during which substance use behaviors accelerate in prevalence, is associated with a particular risk for harm. However, the ability to study each substance class has been limited by their low population prevalence in single population-based cohort studies.
The Monitoring Illicit Substance Use (MISUse) Consortium was established to address this problem by bringing together 4 mature prospective cohort studies across Australia and Zealand: Christchurch Health and Development Study (established 1977; 24 waves; N = 1,265), Australian Temperament Project (established 1983; 16 waves; N = 2,443), Victorian Adolescent Health Cohort Study (established 1992; 11 waves; N = 1,943), and International Youth Development Study (established 2002; 10 waves; N = 2,884).
The MISUse Consortium should enable well-powered studies of the natural history, developmental antecedents, and longer-term consequences of illicit substance use with a focus on identifying modifiable determinants of use that can be targeted in population-level policy and intervention responses.
物质使用的全球影响,包括大麻、安非他明、可卡因、摇头丸、致幻剂和阿片类药物,正在增加,尽管总体患病率较低。澳大利亚和新西兰是世界上少数几个这些类别的物质(通常为非法)使用仍位列疾病负担前10大原因的地区。青春期和青年期,物质使用行为的患病率加速上升,这一时期存在特别的伤害风险。然而,在基于单一人群的队列研究中,由于这些物质在人群中的患病率较低,对每种物质类别的研究能力受到了限制。
成立了非法物质使用监测(MISUse)联盟,通过汇集澳大利亚和新西兰的4项成熟的前瞻性队列研究来解决这一问题:克赖斯特彻奇健康与发展研究(成立于1977年;24轮调查;N = 1265)、澳大利亚气质项目(成立于1983年;16轮调查;N = 2443)、维多利亚青少年健康队列研究(成立于1992年;11轮调查;N = 1943)和国际青年发展研究(成立于2002年;10轮调查;N = 2884)。
MISUse联盟应能开展有充分效力的研究,以探究非法物质使用的自然史、发育前因和长期后果,重点是确定可在人群层面的政策和干预应对措施中作为目标的可改变的使用决定因素。