Wang Si Ming, Zhang Ming Feng, Pan Qian Hui, Yu Ting Feng, Lei Rui Lin, Li Qing Jian
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
These authors contributed equally to this article.
World J Oncol. 2024 Dec;15(6):922-928. doi: 10.14740/wjon1960. Epub 2024 Oct 30.
Gut microbiota (GM) is associated with both the occurrence and development of pancreatic cancer (PC), and immune cells potentially play a role in this process. This study sought to evaluate the causative effect of GM on PC and to ascertain possible immune cell mediators.
The study primarily employed a two-step, two-sample Mendelian randomization (MR) analysis to explore the causal relationship between GM and PC within the European population, placing particular emphasis on the application of the inverse variance weighted (IVW) approach. Additionally, mediation analysis was conducted to explore the potential influence of immune cells as mediators.
The MR analysis revealed a significant association between Geminocystis and the risk of PC. Increased abundance of Geminocystis was positively associated with the risk of PC (odds ratio (OR): 2.580, 95% confidence interval (CI): 1.050 - 6.342). The validity of the outcomes was also verified by the sensitivity analysis. The mediation MR analysis showed that the B-cell absolute count served as a partial intermediary in the causal link between Geminocystis and the risk of PC, contributing to 15.321% of the mediating impact.
This MR study demonstrated that Geminocystis has a causal relationship with PC and potentially mediates B-cell absolute count in the TBNK panel.
肠道微生物群（GM）与胰腺癌（PC）的发生和发展均有关联，免疫细胞可能在此过程中发挥作用。本研究旨在评估GM对PC的因果效应，并确定可能的免疫细胞介导因子。
该研究主要采用两步两样本孟德尔随机化（MR）分析，以探究欧洲人群中GM与PC之间的因果关系，特别强调逆方差加权（IVW）方法的应用。此外，进行中介分析以探究免疫细胞作为介导因子的潜在影响。
MR分析显示，Geminosystis与PC风险之间存在显著关联。Geminosystis丰度增加与PC风险呈正相关（优势比（OR）：2.580，95%置信区间（CI）：1.050 - 6.342）。敏感性分析也验证了结果的有效性。中介MR分析表明，B细胞绝对计数在Geminosystis与PC风险之间的因果联系中起部分中介作用，占中介效应的15.321%。
这项MR研究表明，Geminosystis与PC存在因果关系，并可能介导TBNK组中的B细胞绝对计数。
