Hasnat Hasin, Alam Safaet, Akter Shompa Suriya, Saha Tanoy, Richi Fahmida Tasnim, Hossain Md Hemayet, Zaman Anika, Zeng Chunlai, Shao Chuxiao, Wang Shuanghu, Geng Peiwu, Al Mamun Abdullah
Department of Pharmacy, School of Pharmaceutical Sciences, State University of Bangladesh, Dhaka 1207, Bangladesh.
Chemical Research Division, BCSIR Dhaka Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh.
Saudi Pharm J. 2024 Dec;32(12):102211. doi: 10.1016/j.jsps.2024.102211. Epub 2024 Nov 29.
Natural products have perennially served as a cornerstone for the genesis of novel medicinal compounds. Most clinical therapeutics originate from ancestral herbal remedies and their formulations. Scholars and practitioners have always aimed to extract better remedies to treat various ailments. Genus , consisting of over 800 varieties, is a substantial tree native to tropical regions, characterized by its deciduous or evergreen nature. Various parts of this plant, including its bark, roots, leaves, fruit, and latex, find extensive use in treating a multitude of ailments. This review aims to update the ethnopharmacology, chemistry, and potential clinical applications of extracts and active ingredients from the ten most prevalent species. Major databases like Chemical Abstracts, ScienceDirect, SciFinder, PubMed, Scopus, etc. have all been used to generate references for this review. According to a thorough review of the literature, the many species of have a wide range of biological properties, including antioxidant, cytotoxic, antibacterial, antiviral, antifungal, anti-inflammatory, antiallergenic, antiasthmatic, larvicidal, antiplasmodial, antidiabetic, hepatoprotective and cardioprotective activity. A bunch of different secondary metabolites, such as flavonoids, saponins, alkaloids, tannins, phenolic acids, phytosterols, etc., were also reported, which can be responsible for exerted medicinal actions as well as play a crucial role in the field of new drug discovery and development. However, most species are missing well-controlled and double-blind clinical investigations. Thus, we still recommend further extensive exploration of this miraculous genus.
天然产物一直是新型药用化合物产生的基石。大多数临床治疗药物都源自祖传草药及其配方。学者和从业者一直致力于提取更好的药物来治疗各种疾病。[该属名未给出具体中文译名]属由800多个品种组成，是一种原产于热带地区的大树，具有落叶或常绿的特性。这种植物的各个部位，包括树皮、根、叶、果实和乳胶，在治疗多种疾病方面都有广泛应用。本综述旨在更新十种最常见物种的提取物和活性成分的民族药理学、化学及潜在临床应用。化学文摘、科学Direct、SciFinder、PubMed、Scopus等主要数据库均被用于为本综述生成参考文献。根据对文献的全面综述，[该属名未给出具体中文译名]的许多物种具有广泛的生物学特性，包括抗氧化、细胞毒性、抗菌、抗病毒、抗真菌、抗炎、抗过敏、抗哮喘、杀幼虫、抗疟原虫、抗糖尿病、保肝和心脏保护活性。还报道了一系列不同的次生代谢产物，如黄酮类化合物、皂苷、生物碱、单宁、酚酸、植物甾醇等，它们可能是发挥药用作用的原因，并且在新药发现和开发领域发挥着关键作用。然而，大多数物种缺乏严格对照和双盲的临床研究。因此，我们仍然建议对这个神奇的属进行进一步广泛探索。
