Tevaarwerk G J, Hurst C J, Uksik P, Reese L
Can Med Assoc J. 1979 Oct 20;121(8):1090-3.
The effect of insulin-induced hypoglycemia on serum thyroid hormone concentrations was studied in nine healthy individuals. Before, during and after the hypoglycemia blood samples were taken for measurement of the concentrations of glucose, thyroxine (T(4)), triiodothyronine (T(3)), reverse triiodothyronine (rT(3)), catecholamines and pituitary hormones.There was no change in the mean serum T(4) level (+/- the standard error of the mean) of 67 +/- 2 mug/l. However, the T(3) concentrations rose from a mean basal level of 1.86 +/- 0.06 mug/l to a mean peak of 2.51 +/- 0.21 mug/l (P < 0.01) at 45 minutes after the insulin injection, and the rT(3) concentrations fell from a mean basal level of 0.184 +/- 0.008 mug/l to a mean nadir of 0.171 +/- 0.022 mug/l (not a significant change). The mean peak epinephrine level was 545 +/- 103 ng/l and it occurred between 30 and 45 minutes after the insulin injection; the mean peak norepinephrine level was 584 +/- 114 ng/l and it occurred between 30 and 90 minutes after the injection. The growth hormone levels reached a mean peak of 26.1 +/- 4.8 mug/l and the plasma cortisol levels rose to 215 +/- 9 mug/l. The mean basal prolactin level was 8.5 +/- 0.9 mug/l; in five subjects there was a rise to a mean peak of 50.6 +/- 14.6 mug/l, whereas in the remaining four no significant increase occurred. No correlation was found between the changes in the serum T(3) concentration and any of the other factors studied.It was concluded that acute hypoglycemia is associated with a rapid increase in the serum T(3) concentration.
在9名健康个体中研究了胰岛素诱导的低血糖对血清甲状腺激素浓度的影响。在低血糖发生前、期间和之后采集血样，以测量葡萄糖、甲状腺素（T4）、三碘甲状腺原氨酸（T3）、反三碘甲状腺原氨酸（rT3）、儿茶酚胺和垂体激素的浓度。血清T4平均水平（±平均标准误差）为67±2μg/l，没有变化。然而，T3浓度从平均基础水平1.86±0.06μg/l在胰岛素注射后45分钟升至平均峰值2.51±0.21μg/l（P<0.01），rT3浓度从平均基础水平0.184±0.008μg/l降至平均最低点0.171±0.022μg/l（无显著变化）。肾上腺素平均峰值水平为545±103ng/l，出现在胰岛素注射后30至45分钟之间；去甲肾上腺素平均峰值水平为584±114ng/l，出现在注射后30至90分钟之间。生长激素水平达到平均峰值26.1±4.8μg/l，血浆皮质醇水平升至215±9μg/l。催乳素平均基础水平为8.5±0.9μg/l；5名受试者升至平均峰值50.6±14.6μg/l，而其余4名受试者无显著升高。血清T3浓度变化与所研究的任何其他因素之间均未发现相关性。得出的结论是，急性低血糖与血清T3浓度的快速升高有关。
