Warraich Haider J, Godfrey Sarah, Makwana Bhargav, Abraham Sonu, Aglan Amro, Saji Anu Mariam, Khadke Sumanth, Patel Rushin, Kumar Ashish, Patel Vahin, Parikh Aneri, Banker Ahan, Venesy David, Shah Sachin, Winzelberg Gary S, Nohria Anju, Dani Sourbha S, Ganatra Sarju
Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts, USA.
JACC Adv. 2024 Dec 4;4(1):101431. doi: 10.1016/j.jacadv.2024.101431. eCollection 2025 Jan.
Guidelines recommend palliative care (PC) for patients with heart failure. However, little research has been performed assessing the effect of PC consultation in patients with heart failure with preserved ejection fraction (HFpEF).
The purpose of this study was to investigate the impact of PC consultation on symptom burden and health care utilization among individuals with HFpEF during the last 3 years of their lives.
We retrospectively analyzed electronic medical records from 72 centers, mainly in the United States. All patients with HFpEF, identified using International Classification of Diseases codes, who died within 3 years of the diagnosis were selected and then stratified based on receipt of PC consultation. Propensity score matching was used to control for between-group differences.
Two hundred twenty-six thousand nine hundred twenty-one patients with HFpEF died within 3 years, only 26.4% of whom received a PC consult. In the unmatched cohort, patients who received a PC consult were more likely to be female, Black, and had more comorbidities. After propensity matching, patients receiving PC consultation were less likely to experience an emergency room visit or hospitalization (2.2% vs 4.6%), surgery or anesthesia (1.1% vs 4.2%), critical care (0.7% vs 1.9%), or receive cardiovascular procedures or tests (1.7% vs 4.7%). Furthermore, they were also less likely to have cardiorespiratory symptoms (2.5% vs 5.7%), heart failure exacerbations (1.6% vs 3.3%), cognitive symptoms (1.7% vs 3.4%), falls (0.3% vs 0.6%), and depression or anxiety (1.3% vs 2.8%).
PC consultation is associated with reduced potential unwanted health care utilization and improvement in symptoms in patients with HFpEF in their last 3 years of life. However, PC continues to be underused in this population.
指南推荐为心力衰竭患者提供姑息治疗(PC)。然而,针对射血分数保留的心力衰竭(HFpEF)患者进行PC咨询效果评估的研究较少。
本研究旨在调查PC咨询对HFpEF患者生命最后3年中症状负担和医疗保健利用的影响。
我们回顾性分析了主要来自美国72个中心的电子病历。选取所有使用国际疾病分类代码识别出的HFpEF患者,这些患者在诊断后3年内死亡,然后根据是否接受PC咨询进行分层。采用倾向评分匹配来控制组间差异。
226921例HFpEF患者在3年内死亡,其中仅26.4%接受了PC咨询。在未匹配的队列中,接受PC咨询的患者更可能为女性、黑人,且合并症更多。倾向匹配后,接受PC咨询的患者急诊就诊或住院的可能性更低(2.2%对4.6%),接受手术或麻醉的可能性更低(1.1%对4.2%),接受重症监护的可能性更低(0.7%对1.9%),接受心血管手术或检查的可能性更低(1.7%对4.7%)。此外,他们出现心肺症状(2.5%对5.7%)、心力衰竭加重(1.6%对3.3%)、认知症状(1.7%对3.4%)、跌倒(0.3%对0.6%)以及抑郁或焦虑(1.3%对2.8%)的可能性也更低。
PC咨询与HFpEF患者生命最后3年中潜在不必要的医疗保健利用减少以及症状改善相关。然而,这一人群中PC的使用仍然不足。