Yashaswini Chandrashekar, Kiran Neelakanta Sarvashiva, Chatterjee Ankita
Department of Biotechnology, School of Applied Sciences, REVA University, Bengaluru, Karnataka 560064 India.
J Diabetes Metab Disord. 2024 Dec 16;24(1):3. doi: 10.1007/s40200-024-01539-8. eCollection 2025 Jun.
Zebrafish () have become indispensable models for advancing our understanding of multiple metabolic disorders such as obesity, diabetes mellitus, dyslipidemia, and metabolic syndrome. This review provides a comprehensive analysis of zebrafish as a powerful tool for dissecting the genetic and molecular mechanisms of these diseases, focusing on key genes, like , , , and . Zebrafish offer distinct advantages, including genetic tractability, optical transparency in early development, and the conservation of key metabolic pathways with humans. Studies have successfully used zebrafish to uncover conserved metabolic mechanisms, identify novel disease pathways, and facilitate high-throughput screening of potential therapeutic compounds. The review also highlights the novelty of using zebrafish to model multifactorial metabolic disorders, addressing challenges such as interspecies differences in metabolism and the complexity of human metabolic disease etiology. Moving forward, future research will benefit from integrating advanced omics technologies to map disease-specific molecular signatures, applying personalized medicine approaches to optimize treatments, and utilizing computational models to predict therapeutic outcomes. By embracing these innovative strategies, zebrafish research has the potential to revolutionize the diagnosis, treatment, and prevention of metabolic disorders, offering new avenues for translational applications. Continued interdisciplinary collaboration and investment in zebrafish-based studies will be crucial to fully harnessing their potential for advancing therapeutic development.
斑马鱼已成为推进我们对多种代谢紊乱（如肥胖、糖尿病、血脂异常和代谢综合征）理解的不可或缺的模型。本综述全面分析了斑马鱼作为剖析这些疾病遗传和分子机制的有力工具，重点关注关键基因，如[具体基因1]、[具体基因2]、[具体基因3]和[具体基因4]。斑马鱼具有独特优势，包括遗传易处理性、早期发育阶段的光学透明性以及与人类关键代谢途径的保守性。研究已成功利用斑马鱼揭示保守的代谢机制、识别新的疾病途径并促进对潜在治疗化合物的高通量筛选。该综述还强调了利用斑马鱼模拟多因素代谢紊乱的新颖性，探讨了诸如代谢种间差异和人类代谢疾病病因复杂性等挑战。展望未来，未来研究将受益于整合先进的组学技术以绘制疾病特异性分子特征图谱、应用个性化医疗方法优化治疗以及利用计算模型预测治疗结果。通过采用这些创新策略，斑马鱼研究有潜力彻底改变代谢紊乱的诊断、治疗和预防，为转化应用提供新途径。持续的跨学科合作以及对基于斑马鱼研究的投资对于充分发挥其推进治疗开发的潜力至关重要。
