Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden; Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China.
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden; Department of Medical Cell Biology, Uppsala University, Biomedical Centre, Uppsala, Sweden.
Trends Mol Med. 2024 Oct;30(10):932-949. doi: 10.1016/j.molmed.2024.05.002. Epub 2024 Jun 1.
The zebrafish has become an outstanding model for studying organ development and tissue regeneration, which is prominently leveraged for studies of pancreatic development, insulin-producing β-cells, and diabetes. Although studied for more than two decades, many aspects remain elusive and it has only recently been possible to investigate these due to technical advances in transcriptomics, chemical-genetics, genome editing, drug screening, and in vivo imaging. Here, we review recent findings on zebrafish pancreas development, β-cell regeneration, and how zebrafish can be used to provide novel insights into gene functions, disease mechanisms, and therapeutic targets in diabetes, inspiring further use of zebrafish for the development of novel therapies for diabetes.
斑马鱼已成为研究器官发育和组织再生的杰出模型，这在胰腺发育、胰岛素分泌β细胞和糖尿病的研究中得到了广泛应用。尽管已经研究了二十多年，但许多方面仍然难以捉摸，直到最近由于转录组学、化学遗传学、基因组编辑、药物筛选和体内成像等技术的进步，才有可能对这些方面进行研究。在这里，我们回顾了斑马鱼胰腺发育、β细胞再生的最新发现，以及斑马鱼如何用于为糖尿病中的基因功能、疾病机制和治疗靶点提供新的见解，这激发了进一步利用斑马鱼开发糖尿病新疗法的研究。
