Kocaman Nevin, Onat Elif, Hançer Serhat
Department of Histology and Embryology, Firat University Faculty of Medicine, Elâzığ, TUR.
Department of Medical Pharmacology, Adıyaman University Faculty of Medicine, Adıyaman, TUR.
Cureus. 2024 Nov 18;16(11):e73889. doi: 10.7759/cureus.73889. eCollection 2024 Nov.
In this study, we aimed to investigate whether hydroxytyrosol (HT) has a protective effect on corn syrup-induced kidney damage in rats and the role of podocalyxin (PCX) and pentraxin-3 (PTX3) in this possible effect.
Rats were divided into four groups with six rats in each group: 1) control, 2) HT, 3) corn syrup, and 4) corn syrup + HT. Rats were given 30% corn syrup added to their drinking water for six weeks. HT was given orally at 4 ml/kg/day, alone and together with corn syrup. PCX and PTX3 in the renal tissue were assessed through histopathological examination. Biochemical parameters were also examined in the sera with the ELISA method.
In this study, it was observed that PCX and PTX3 levels, which increased as a result of corn syrup administration, decreased after HT treatment (p < 0.001). The increase in amylase, lipase, and insulin levels because of corn syrup consumption decreased with HT consumption (p = 0.001, p < 0.001, p = 0.003, respectively). It was determined that the increase in erythrocyte extravasation, exudate accumulation, and fibrosis observed in the kidney tissue with corn syrup application decreased as a result of HT application (p < 0.001).
It is thought that HT has a protective effect against kidney damage caused by corn syrup and that PCX and PTX3 may play a role in this effect.
在本研究中，我们旨在调查羟基酪醇（HT）是否对玉米糖浆诱导的大鼠肾损伤具有保护作用，以及足萼蛋白（PCX）和五聚素3（PTX3）在这种可能的作用中所起的作用。
将大鼠分为四组，每组六只：1）对照组，2）HT组，3）玉米糖浆组，4）玉米糖浆+HT组。给大鼠饮用添加了30%玉米糖浆的水，持续六周。HT单独以及与玉米糖浆一起以4 ml/kg/天的剂量口服给药。通过组织病理学检查评估肾组织中的PCX和PTX3。还采用酶联免疫吸附测定法检测血清中的生化参数。
在本研究中，观察到由于给予玉米糖浆而升高的PCX和PTX3水平在HT治疗后降低（p < 0.001）。由于食用玉米糖浆导致的淀粉酶、脂肪酶和胰岛素水平升高随着HT的食用而降低（分别为p = 0.001、p < 0.001、p = 0.003）。确定了应用玉米糖浆后在肾组织中观察到的红细胞外渗、渗出物积聚和纤维化增加，由于应用HT而减少（p < 0.001）。
认为HT对玉米糖浆引起的肾损伤具有保护作用，并且PCX和PTX3可能在这种作用中发挥作用。
