膳食果糖与果糖诱导的病理生理学改变
Dietary Fructose and Fructose-Induced Pathologies.
机构信息
Department of Biological Chemistry, University of California, Irvine, California, USA; email:
Institute of Bioengineering, Bio-MAX, Seoul National University, Seoul, South Korea.
出版信息
Annu Rev Nutr. 2022 Aug 22;42:45-66. doi: 10.1146/annurev-nutr-062220-025831.
Abstract
The consumption of fructose as sugar and high-fructose corn syrup has markedly increased during the past several decades. This trend coincides with the exponential rise of metabolic diseases, including obesity, nonalcoholic fatty liver disease, cardiovascular disease, and diabetes. While the biochemical pathways of fructose metabolism were elucidated in the early 1990s, organismal-level fructose metabolism and its whole-body pathophysiological impacts have been only recently investigated. In this review, we discuss the history of fructose consumption, biochemical and molecular pathways involved in fructose metabolism in different organs and gut microbiota, the role of fructose in the pathogenesis of metabolic diseases, and the remaining questions to treat such diseases.
摘要
在过去几十年中，果糖（作为糖和高果糖玉米糖浆的形式）的消耗量显著增加。这一趋势与代谢疾病（包括肥胖、非酒精性脂肪肝疾病、心血管疾病和糖尿病）的指数级增长相吻合。虽然果糖代谢的生化途径在 20 世纪 90 年代初就已阐明，但果糖在不同器官和肠道微生物群中的代谢及其全身病理生理学影响直到最近才得到研究。在这篇综述中，我们讨论了果糖消费的历史、不同器官和肠道微生物群中果糖代谢的生化和分子途径、果糖在代谢疾病发病机制中的作用以及治疗这些疾病的尚存问题。
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